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arf-6 ADP-ribosylation factor 6 [ Caenorhabditis elegans ]

Gene ID: 191608, updated on 18-Sep-2024

Summary

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Official Symbol
arf-6
Official Full Name
ADP-ribosylation factor 6
Primary source
WormBase:WBGene00000184
Locus tag
CELE_Y116A8C.12
See related
AllianceGenome:WB:WBGene00000184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Is expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (16947120..16949564)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Rab-like protein 3 Neighboring gene ncRNA Neighboring gene ABC2_membrane domain-containing protein;Transmembrane protein 185B Neighboring gene DNA repair and recombination protein RAD54-like Neighboring gene Peptidase S54 rhomboid domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Science in Suzhou: establishment and function of neural circuits. Scott K, et al. EMBO Rep, 2012 Apr 2. PMID 22402665, Free PMC Article
  2. SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity. Chen D, et al. J Cell Biol, 2018 Jun 4. PMID 29563216, Free PMC Article
  3. BMP signaling requires retromer-dependent recycling of the type I receptor. Gleason RJ, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550286, Free PMC Article
  4. Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans. Dang H, et al. Mol Biol Cell, 2004 Jan. PMID 14565969, Free PMC Article
  5. RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death. Kutscher LM, et al. Dev Cell, 2018 Oct 22. PMID 30220571, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endosome to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADP-ribosylation factor 6
NP_503011.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    16947120..16949564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070610.6 → NP_503011.1  ADP-ribosylation factor 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503011.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2S4
    Conserved Domains (1) summary
    cd04149
    Location:5 → 172
    Arf6; ADP ribosylation factor 6 (Arf6)
Nucleotide Protein
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