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Klk6 kallikrein related-peptidase 6 [ Mus musculus (house mouse) ]

Gene ID: 19144, updated on 2-Nov-2024

Summary

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Official Symbol
Klk6provided by MGI
Official Full Name
kallikrein related-peptidase 6provided by MGI
Primary source
MGI:MGI:1343166
See related
Ensembl:ENSMUSG00000050063 AllianceGenome:MGI:1343166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BSP; MSP; Bssp; Klk29; Prss9; Prss18; neurosin
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway; protein maturation; and regulation of neuron projection development. Is active in cornified envelope. Is expressed in several structures, including brain. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 16.1), stomach adult (RPKM 3.3) and 2 other tissues See more
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Genomic context

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See Klk6 in Genome Data Viewer
Location:
7 B3; 7 28.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43473967..43481219)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43824438..43832027)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 8 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Neighboring gene kallikrein related-peptidase 5 Neighboring gene predicted gene 45173

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter. Furube E, et al. Neurochem Res, 2023 Sep. PMID 37067738
  2. In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins. Murakami K, et al. Neuroscience, 2013 Apr 16. PMID 23376368
  3. Myofibril-bound serine protease and its endogenous inhibitor in mouse: extraction, partial characterization and effect on myofibrils. Sangorrín MP, et al. Comp Biochem Physiol B Biochem Mol Biol, 2002 Apr. PMID 11923084
  4. Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis. Breitenbach U, et al. J Invest Dermatol, 2001 Sep. PMID 11564170
  5. Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis. Yoon H, et al. Biol Chem, 2016 Dec 1. PMID 27533119, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter.
    Title: Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter.
  2. KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages.
    Title: KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages.
  3. Blocking Kallikrein 6 promotes developmental myelination.
    Title: Blocking Kallikrein 6 promotes developmental myelination.
  4. Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.
    Title: Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.
  5. KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
    Title: KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
  6. Elimination of Klk6 in Spink5 KO mice (model for Netherton syndrome (NS) remarkably suppresses the expression of Tslp, a major itching-inducing factor and driver of allergic reactions during differentiation of epidermal keratinocytes. Study demonstrated for the first time that KLK6 is implicated in skin inflammation and may represent a novel druggable target for NS and other inflammatory conditions e.g. atopic dermatitis.
    Title: A proinflammatory role of KLK6 protease in Netherton syndrome.
  7. The data are exciting because they demonstrate that Klk6 can influence astrocyte plasticity through receptor-dependent mechanisms.
    Title: Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms.
  8. expression strongly induced in psoriasiform epidermis; crucial for development of imiquimod-induced psoriasiform dermatitis
    Title: Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.
  9. Kallikrein 6 secreted by oligodendrocytes plays a critical role in the pathogenesis of experimental autoimmune encephalomyelitis.
    Title: Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis.
  10. Data show that kallikrein 6 (KLK6) expression is induced in mouse and human skin during chronic glucocorticoid treatment.
    Title: Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kallikrein-6
Names
brain serine protease
kallikrein 29
kallikrein 6
myelencephalon-specific protease
myofibril-bound protease
protease M
protease, serine, 18
protease, serine, 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164696.2 → NP_001158168.1  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_001158168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Related
    ENSMUSP00000103600.4, ENSMUST00000107966.10
    Conserved Domains (1) summary
    smart00020
    Location:28 → 244
    Tryp_SPc; Trypsin-like serine protease

  2. NM_001164697.2 → NP_001158169.1  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_001158169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Related
    ENSMUSP00000103602.4, ENSMUST00000107968.10
    Conserved Domains (1) summary
    smart00020
    Location:28 → 244
    Tryp_SPc; Trypsin-like serine protease

  3. NM_001164698.2 → NP_001158170.1  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_001158170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Conserved Domains (1) summary
    smart00020
    Location:28 → 244
    Tryp_SPc; Trypsin-like serine protease

  4. NM_001417156.1 → NP_001404085.1  kallikrein-6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC134858
    UniProtKB/TrEMBL
    Q91Y82

  5. NM_011177.3 → NP_035307.2  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_035307.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Related
    ENSMUSP00000103601.2, ENSMUST00000107967.3
    Conserved Domains (1) summary
    smart00020
    Location:28 → 244
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43473967..43481219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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