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Klk6 kallikrein related-peptidase 6 [ Mus musculus (house mouse) ]

Gene ID: 19144, updated on 6-Jun-2024

Summary

Official Symbol
Klk6provided by MGI
Official Full Name
kallikrein related-peptidase 6provided by MGI
Primary source
MGI:MGI:1343166
See related
Ensembl:ENSMUSG00000050063 AllianceGenome:MGI:1343166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BSP; MSP; Bssp; Klk29; Prss9; Prss18; neurosin
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway and regulation of neuron projection development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in secretory granule. Is expressed in several structures, including brain. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 16.1), stomach adult (RPKM 3.3) and 2 other tissues See more
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Genomic context

See Klk6 in Genome Data Viewer
Location:
7 B3; 7 28.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43473967..43481219)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43824438..43832027)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 8 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Neighboring gene kallikrein related-peptidase 5 Neighboring gene predicted gene 45173

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
kallikrein-6
Names
brain serine protease
kallikrein 29
kallikrein 6
myelencephalon-specific protease
myofibril-bound protease
protease M
protease, serine, 18
protease, serine, 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164696.2NP_001158168.1  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_001158168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Related
    ENSMUSP00000103600.4, ENSMUST00000107966.10
    Conserved Domains (1) summary
    smart00020
    Location:28244
    Tryp_SPc; Trypsin-like serine protease
  2. NM_001164697.2NP_001158169.1  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_001158169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Related
    ENSMUSP00000103602.4, ENSMUST00000107968.10
    Conserved Domains (1) summary
    smart00020
    Location:28244
    Tryp_SPc; Trypsin-like serine protease
  3. NM_001164698.2NP_001158170.1  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_001158170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Conserved Domains (1) summary
    smart00020
    Location:28244
    Tryp_SPc; Trypsin-like serine protease
  4. NM_001417156.1NP_001404085.1  kallikrein-6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC134858
    UniProtKB/TrEMBL
    O88301, Q91Y82
  5. NM_011177.3NP_035307.2  kallikrein-6 precursor

    See identical proteins and their annotated locations for NP_035307.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC134858
    Consensus CDS
    CCDS21184.2
    UniProtKB/TrEMBL
    O88301, Q91Y82
    Related
    ENSMUSP00000103601.2, ENSMUST00000107967.3
    Conserved Domains (1) summary
    smart00020
    Location:28244
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43473967..43481219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)