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St14 suppression of tumorigenicity 14 (colon carcinoma) [ Mus musculus (house mouse) ]

Gene ID: 19143, updated on 26-Sep-2022

Summary

Official Symbol
St14provided by MGI
Official Full Name
suppression of tumorigenicity 14 (colon carcinoma)provided by MGI
Primary source
MGI:MGI:1338881
See related
Ensembl:ENSMUSG00000031995 AllianceGenome:MGI:1338881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mCAP3; MT-SP1; Prss14; Epithin; Tmprss14; matriptase
Summary
Enables serine-type endopeptidase activity. Acts upstream of or within epithelial cell morphogenesis involved in placental branching and neural tube closure. Located in extracellular region. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; pituitary gland; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 92.3), small intestine adult (RPKM 64.9) and 12 other tissues See more
Orthologs
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Genomic context

See St14 in Genome Data Viewer
Location:
9 A4; 9 16.61 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (30999886..31043138, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31088590..31131811, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29724 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene predicted gene, 17508 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene amyloid beta (A4) precursor-like protein 2 Neighboring gene protein CEBPZOS pseudogene Neighboring gene predicted gene, 33535

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis involved in placental branching IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
suppressor of tumorigenicity 14 protein homolog
Names
matriptase/MT-SP1
protease, serine, 14 (epithin)
NP_035306.2
XP_006510161.1
XP_006510162.1
XP_036010597.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011176.4NP_035306.2  suppressor of tumorigenicity 14 protein homolog

    See identical proteins and their annotated locations for NP_035306.2

    Status: VALIDATED

    Source sequence(s)
    AC114542, CT025653
    Consensus CDS
    CCDS22948.1
    UniProtKB/Swiss-Prot
    P56677
    UniProtKB/TrEMBL
    Q543E3
    Related
    ENSMUSP00000034478.3, ENSMUST00000034478.3
    Conserved Domains (5) summary
    smart00020
    Location:614849
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:340444
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:525559
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:615852
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:88179
    SEA; SEA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    30999886..31043138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510098.5XP_006510161.1  suppressor of tumorigenicity 14 protein homolog isoform X2

    Conserved Domains (4) summary
    cd00041
    Location:318422
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:503537
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:593830
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:66156
    SEA; SEA domain
  2. XM_006510099.5XP_006510162.1  suppressor of tumorigenicity 14 protein homolog isoform X3

    Conserved Domains (3) summary
    cd00041
    Location:168272
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:353387
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:443680
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_036154704.1XP_036010597.1  suppressor of tumorigenicity 14 protein homolog isoform X1

    Conserved Domains (4) summary
    cd00041
    Location:360464
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:545579
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:635872
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:108198
    SEA; SEA domain