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Lgmn legumain [ Mus musculus (house mouse) ]

Gene ID: 19141, updated on 5-Mar-2024

Summary

Official Symbol
Lgmnprovided by MGI
Official Full Name
legumainprovided by MGI
Primary source
MGI:MGI:1330838
See related
Ensembl:ENSMUSG00000021190 AllianceGenome:MGI:1330838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AEP; Prsc1
Summary
This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]
Expression
Broad expression in kidney adult (RPKM 276.6), placenta adult (RPKM 128.8) and 20 other tissues See more
Orthologs
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Genomic context

See Lgmn in Genome Data Viewer
Location:
12 E; 12 51.45 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102360341..102405987, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102394082..102439728, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene Ras and Rab interactor 3 Neighboring gene STARR-seq mESC enhancer starr_33096 Neighboring gene STARR-positive B cell enhancer ABC_E1862 Neighboring gene STARR-positive B cell enhancer ABC_E7170 Neighboring gene STARR-positive B cell enhancer ABC_E3066 Neighboring gene STARR-positive B cell enhancer ABC_E9150 Neighboring gene STARR-positive B cell enhancer ABC_E7171 Neighboring gene predicted gene, 30198 Neighboring gene STARR-seq mESC enhancer starr_33098 Neighboring gene golgin A5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables endopeptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of ERBB signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in self proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in vacuolar protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
legumain
Names
asparaginyl endopeptidase
preprolegumain
protease, cysteine, 1
NP_001365804.1
NP_035305.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378875.1NP_001365804.1  legumain preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC122302
    UniProtKB/Swiss-Prot
    O89017
    UniProtKB/TrEMBL
    A2RTI3
    Related
    ENSMUSP00000105647.2, ENSMUST00000110020.8
    Conserved Domains (2) summary
    pfam01650
    Location:31287
    Peptidase_C13; Peptidase C13 family
    cd21115
    Location:311431
    legumain_C; C-terminal prodomain of legumain
  2. NM_011175.4NP_035305.1  legumain preproprotein

    See identical proteins and their annotated locations for NP_035305.1

    Status: REVIEWED

    Source sequence(s)
    AC122302
    Consensus CDS
    CCDS26119.1
    UniProtKB/Swiss-Prot
    O89017
    UniProtKB/TrEMBL
    A2RTI3
    Related
    ENSMUSP00000021607.9, ENSMUST00000021607.9
    Conserved Domains (2) summary
    pfam01650
    Location:31287
    Peptidase_C13; Peptidase C13 family
    cd21115
    Location:311431
    legumain_C; C-terminal prodomain of legumain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    102360341..102405987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)