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LGMN legumain [ Homo sapiens (human) ]

Gene ID: 5641, updated on 1-Jun-2020

Summary

Official Symbol
LGMNprovided by HGNC
Official Full Name
legumainprovided by HGNC
Primary source
HGNC:HGNC:9472
See related
Ensembl:ENSG00000100600 MIM:602620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AEP; LGMN1; PRSC1
Summary
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 135.7), spleen (RPKM 98.7) and 23 other tissues See more
Orthologs

Genomic context

See LGMN in Genome Data Viewer
Location:
14q32.12
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (92703809..92748627, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93170152..93215047, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370707 Neighboring gene Ras and Rab interactor 3 Neighboring gene golgin A5 Neighboring gene long intergenic non-protein coding RNA 2833

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of legumain (LGMN) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
associative learning ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to amyloid-beta IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
memory ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of ERBB signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
proteolysis involved in cellular protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis involved in cellular protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis involved in cellular protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
receptor catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
renal system process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
self proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
vacuolar protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vitamin D metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endolysosome lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
late endosome TAS
Traceable Author Statement
more info
PubMed 
lysosomal lumen TAS
Traceable Author Statement
more info
 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosome TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
legumain
Names
asparaginyl endopeptidase
cysteine protease 1
protease, cysteine 1
protease, cysteine, 1 (legumain)
NP_001008530.1
NP_001350625.1
NP_001350628.1
NP_005597.3
XP_005267919.1
XP_005267920.1
XP_011535272.1
XP_016876952.1
XP_016876953.1
XP_016876954.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008530.3NP_001008530.1  legumain isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001008530.1

    Status: REVIEWED

    Source sequence(s)
    BX161434, CD366588, DA347449
    Consensus CDS
    CCDS9904.1
    UniProtKB/Swiss-Prot
    Q99538
    UniProtKB/TrEMBL
    Q53XC6
    Related
    ENSP00000376911.2, ENST00000393218.6
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  2. NM_001363696.2NP_001350625.1  legumain isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL132987, AL136332
    Consensus CDS
    CCDS86424.1
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  3. NM_001363699.2NP_001350628.1  legumain isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL132987, AL136332
    Consensus CDS
    CCDS86423.1
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  4. NM_005606.7NP_005597.3  legumain isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005597.3

    Status: REVIEWED

    Source sequence(s)
    AL132987, AL136332, BC013678, CD366588
    Consensus CDS
    CCDS9904.1
    UniProtKB/Swiss-Prot
    Q99538
    UniProtKB/TrEMBL
    Q53XC6, Q96CY7
    Related
    ENSP00000334052.4, ENST00000334869.9
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    92703809..92748627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267863.4XP_005267920.1  legumain isoform X4

    See identical proteins and their annotated locations for XP_005267920.1

    UniProtKB/Swiss-Prot
    Q99538
    Related
    ENSP00000451861.1, ENST00000555699.5
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  2. XM_005267862.4XP_005267919.1  legumain isoform X3

    See identical proteins and their annotated locations for XP_005267919.1

    UniProtKB/Swiss-Prot
    Q99538
    Related
    ENSP00000452572.1, ENST00000557434.5
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  3. XM_011536970.2XP_011535272.1  legumain isoform X2

    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  4. XM_017021463.1XP_016876952.1  legumain isoform X1

    UniProtKB/Swiss-Prot
    Q99538
    UniProtKB/TrEMBL
    Q53XC6
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  5. XM_017021465.1XP_016876954.1  legumain isoform X1

    UniProtKB/Swiss-Prot
    Q99538
    UniProtKB/TrEMBL
    Q53XC6
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
  6. XM_017021464.1XP_016876953.1  legumain isoform X1

    UniProtKB/Swiss-Prot
    Q99538
    UniProtKB/TrEMBL
    Q53XC6
    Conserved Domains (1) summary
    pfam01650
    Location:29285
    Peptidase_C13; Peptidase C13 family
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