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Prkcsh protein kinase C substrate 80K-H [ Mus musculus (house mouse) ]

Gene ID: 19089, updated on 12-Aug-2018

Summary

Official Symbol
Prkcshprovided by MGI
Official Full Name
protein kinase C substrate 80K-Hprovided by MGI
Primary source
MGI:MGI:107877
See related
Ensembl:ENSMUSG00000003402 Vega:OTTMUSG00000062326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
80K-H; PKCSH
Expression
Ubiquitous expression in adrenal adult (RPKM 75.3), duodenum adult (RPKM 65.8) and 28 other tissues See more
Orthologs

Genomic context

See Prkcsh in Genome Data Viewer
Location:
9 A3; 9 8.04 cM
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (22002988..22014245)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (21807479..21818666)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator-like 3 Neighboring gene predicted gene, 36414 Neighboring gene coiled-coil domain containing 151 Neighboring gene ELAV like RNA binding protein 3 Neighboring gene zinc finger protein 653 Neighboring gene predicted gene, 16845

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
N-glycan processing ISO
Inferred from Sequence Orthology
more info
 
N-glycan processing TAS
Traceable Author Statement
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitrogen compound metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
renal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
glucosidase II complex IDA
Inferred from Direct Assay
more info
PubMed 
glucosidase II complex IPI
Inferred from Physical Interaction
more info
PubMed 
glucosidase II complex ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glucosidase 2 subunit beta
Names
alpha glucosidase II, beta-subunit
carbohydrate processing enzyme of the endoplasmic reticulum
glucosidase II beta-subunit
hepatocystin
protein kinase C substrate 60.1 kDa protein heavy chain
NP_001280579.1
NP_001280580.1
NP_032951.1
XP_006510158.1
XP_006510159.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293650.1NP_001280579.1  glucosidase 2 subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_001280579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163623, AK137661, BY295975, CX207653
    Consensus CDS
    CCDS80967.1
    UniProtKB/Swiss-Prot
    O08795
    UniProtKB/TrEMBL
    Q3U518
    Related
    ENSMUSP00000110987.2, OTTMUSP00000078823, ENSMUST00000115331.9, OTTMUST00000152027
    Conserved Domains (3) summary
    pfam12999
    Location:21163
    PRKCSH-like; Glucosidase II beta subunit-like
    cl06793
    Location:380508
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:114256
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. NM_001293651.1NP_001280580.1  glucosidase 2 subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_001280580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    AC163623, AK137661, BY295975, CD807078
    Consensus CDS
    CCDS22918.1
    UniProtKB/Swiss-Prot
    O08795
    UniProtKB/TrEMBL
    Q3U518
    Related
    ENSMUSP00000149936.1, OTTMUSP00000078821, ENSMUST00000216344.1, OTTMUST00000152025
    Conserved Domains (3) summary
    pfam12999
    Location:21163
    PRKCSH-like; Glucosidase II beta subunit-like
    cl06793
    Location:373501
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:114256
    ATP-synt_B; ATP synthase B/B' CF(0)
  3. NM_008925.2NP_032951.1  glucosidase 2 subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_032951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    AC163623, AK137661, BY295975
    Consensus CDS
    CCDS22918.1
    UniProtKB/Swiss-Prot
    O08795
    UniProtKB/TrEMBL
    Q3U518
    Related
    ENSMUSP00000003493.7, OTTMUSP00000078822, ENSMUST00000003493.8, OTTMUST00000152026
    Conserved Domains (3) summary
    pfam12999
    Location:21163
    PRKCSH-like; Glucosidase II beta subunit-like
    cl06793
    Location:373501
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:114256
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    22002988..22014245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510095.3XP_006510158.1  glucosidase 2 subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006510158.1

    UniProtKB/Swiss-Prot
    O08795
    Conserved Domains (3) summary
    pfam12999
    Location:21163
    PRKCSH-like; Glucosidase II beta subunit-like
    cl06793
    Location:380508
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:114256
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. XM_006510096.2XP_006510159.1  glucosidase 2 subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006510159.1

    UniProtKB/Swiss-Prot
    O08795
    Conserved Domains (3) summary
    pfam12999
    Location:21163
    PRKCSH-like; Glucosidase II beta subunit-like
    cl06793
    Location:380508
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:114256
    ATP-synt_B; ATP synthase B/B' CF(0)
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