Conserved Protein Domain Family
PRKCSH-like
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pfam12999: PRKCSH-like 
Glucosidase II beta subunit-like
The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.
Links
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Statistics
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PSSM-Id: 372423
Aligned: 5 rows
Threshold Bit Score: 289.382
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001485524   2 ILVPLIGICALIAGR-VDAIRGVEPTRLHLYEPSvENNEkyWHCLNHPEIKLRFDQVNDDFCDCPDGSDEPGTNACpYNG 80 
XP_002546231  53 MLQNVLAIGLLVPIA-LGKLRGVSPDNEHLYQPTiENGQqyWHCLNDSSIKLSFDQVNDDYCDCPDGSDEPGTNAC-SKP 130
CAY70155       5 LTIGSIAVSLFPASAeIPPLRGVAPDLLEKYVPD-KDGN--WKCLGHPEIVLHFDQVNDDYCDCPDGSDEPGTAAC-ENG 80 
XP_002174674   9 FFLPWL-LQVAVSDA-KTEVLGVSPKELNLYQPD-ENGN--WKCLNSSKV-ISFSQVNDDYCDCPDGSDEPGTSAC-QNG 81 
Q9USH8         9 LTAPLLISSLYTVNA-ANDLRGVASDKSDLYKPD-AKGN--WKCLGSDKL-ISFNQVNDDYCDCPDGSDEPGTSAC-HNG 82  Schizosaccharom...

XP_001485524  81 ssKFYCANNGFIPGYLESFKLNDGVCDYDICCDGSDEa--EGVCPDKCHEIAQQFRKFSDEANNDMKILLKIKQKLQLAV 158
XP_002546231 131 lfKFYCTNEGHFPGYIDQFKVDDGICDYDICCDGSDE---LGICENKCGEIHRQFEEYQTKVEKSISGALSRKEGILAIA 207
CAY70155      81 --KFYCANEGFEPNFIPTFLVDDGVCDYKVCCDGSDEk--SGKCPNRCLELAEKAELLRLERKARLENGLKAKRDLIVQS 156
XP_002174674  82 --RFFCVNKGYISTYIPSNRVNDGLCD---CCDGSDEymeIVHCENTCNEKAAVYLDELNEHNNQVRKGIDIRNEWVRAA 156
Q9USH8        83 --KFFCKNTGYISSYIPSNRVDDTVCD---CCDGSDEs--LIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALES 155 Schizosaccharom...

XP_001485524 159 QKKVDDITKKLQILKDELKKRQQRA 183
XP_002546231 208 KRKRDHLINQLKKLEQSLPAKKMEL 232
CAY70155     157 QNKLREISQRRAELEKTIQLEQQQL 181
XP_002174674 157 EVKNEELKKIYDENNSKMLATMKRK 181
Q9USH8       156 AKKTDEVKARYKEISDSLVAVSAEK 180 Schizosaccharomyces pombe 972h-
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