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Prkar1b protein kinase, cAMP dependent regulatory, type I beta [ Mus musculus (house mouse) ]

Gene ID: 19085, updated on 8-Jan-2023

Summary

Official Symbol
Prkar1bprovided by MGI
Official Full Name
protein kinase, cAMP dependent regulatory, type I betaprovided by MGI
Primary source
MGI:MGI:97759
See related
Ensembl:ENSMUSG00000025855 AllianceGenome:MGI:97759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIbeta
Summary
Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Involved in modulation of chemical synaptic transmission and regulation of synaptic vesicle cycle. Acts upstream of or within learning or memory. Located in hippocampal mossy fiber to CA3 synapse and multivesicular body. Part of cAMP-dependent protein kinase complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 158.4), frontal lobe adult (RPKM 140.4) and 6 other tissues See more
Orthologs
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Genomic context

See Prkar1b in Genome Data Viewer
Location:
5 G2; 5 77.74 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139003059..139136458, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139017304..139150703, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38726 Neighboring gene platelet derived growth factor, alpha Neighboring gene dynein, axonemal assembly factor 5 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene golgi to ER traffic protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables cAMP-dependent protein kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cAMP-dependent protein kinase type I-beta regulatory subunit
Names
cAMP dependent regulatory type I beta subunit transcript 1
cAMP dependent regulatory type I beta subunit transcript 2
cAMP dependent regulatory type I beta subunit transcript 3
cAMP dependent regulatory type I beta subunit transcript 4
NP_001240819.1
NP_001346026.1
NP_001346027.1
NP_001346028.1
NP_001346029.1
NP_001346030.1
NP_032949.3
XP_006504723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253890.1NP_001240819.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

    See identical proteins and their annotated locations for NP_001240819.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AK158994, AK161621, BU560122, BU844021, CJ290554, CK332907
    Consensus CDS
    CCDS19803.1
    UniProtKB/Swiss-Prot
    P12849
    UniProtKB/TrEMBL
    A0A6P5PX57, Q3TY04
    Related
    ENSMUSP00000106515.2, ENSMUST00000110890.8
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. NM_001359097.1NP_001346026.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC117698, AC125065
    Consensus CDS
    CCDS19803.1
    UniProtKB/Swiss-Prot
    P12849
    UniProtKB/TrEMBL
    A0A6P5PX57
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. NM_001359098.1NP_001346027.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC117698, JF720023
    Consensus CDS
    CCDS19803.1
    UniProtKB/Swiss-Prot
    P12849
    UniProtKB/TrEMBL
    A0A6P5PX57
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. NM_001359099.1NP_001346028.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC117698, AC125065
    Consensus CDS
    CCDS19803.1
    UniProtKB/Swiss-Prot
    P12849
    UniProtKB/TrEMBL
    A0A6P5PX57
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  5. NM_001359100.1NP_001346029.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC117698, AC125065
    Consensus CDS
    CCDS19803.1
    UniProtKB/Swiss-Prot
    P12849
    UniProtKB/TrEMBL
    A0A6P5PX57
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  6. NM_001359101.1NP_001346030.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC117698, AC125065
    Consensus CDS
    CCDS90004.1
    UniProtKB/TrEMBL
    D3Z0V6
    Related
    ENSMUSP00000106514.2, ENSMUST00000110889.8
    Conserved Domains (1) summary
    cd00038
    Location:131246
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  7. NM_008923.3NP_032949.3  cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

    See identical proteins and their annotated locations for NP_032949.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AK158994, AK161621, BB429442, BY237508, CD775616, CO425808
    Consensus CDS
    CCDS19803.1
    UniProtKB/Swiss-Prot
    P12849
    UniProtKB/TrEMBL
    A0A6P5PX57, Q3TY04
    Related
    ENSMUSP00000026973.8, ENSMUST00000026973.14
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139003059..139136458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504660.4XP_006504723.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    See identical proteins and their annotated locations for XP_006504723.1

    UniProtKB/Swiss-Prot
    P12849
    UniProtKB/TrEMBL
    A0A6P5PX57
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...