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PRKAR1B protein kinase cAMP-dependent type I regulatory subunit beta [ Homo sapiens (human) ]

Gene ID: 5575, updated on 3-Dec-2024

Summary

Official Symbol
PRKAR1Bprovided by HGNC
Official Full Name
protein kinase cAMP-dependent type I regulatory subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9390
See related
Ensembl:ENSG00000188191 MIM:176911; AllianceGenome:HGNC:9390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MASNS; PRKAR1
Summary
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Biased expression in brain (RPKM 53.5), ovary (RPKM 6.9) and 11 other tissues See more
Orthologs
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Genomic context

See PRKAR1B in Genome Data Viewer
Location:
7p22.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (549197..728934, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (650161..832029, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (588834..767313, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:499317-500044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:500045-500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:510601-511557 Neighboring gene Sharpr-MPRA regulatory region 3057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:515046-515940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:519557-520077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:530277-531056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:531057-531836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:535084-536005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:536006-536926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:543335-544112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:549933-550440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:550441-550948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:551965-552472 Neighboring gene Sharpr-MPRA regulatory region 8552 Neighboring gene NANOG hESC enhancer GRCh37_chr7:555259-555760 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:556430-557352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:558275-559196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:561041-561962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17812 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:570324-570520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:572659-573216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:578299-579242 Neighboring gene platelet derived growth factor subunit A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:579243-580184 Neighboring gene PDGFA divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:592082-592582 Neighboring gene PRKAR1B antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:611753-612521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:612522-613291 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:630646-630792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:643285-643970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25473 Neighboring gene PRKAR1B antisense RNA 1 Neighboring gene uncharacterized LOC105375119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:653082-653582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:653583-654083 Neighboring gene MPRA-validated peak6334 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:690976-692175 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:715563-715737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:736050-736550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:736551-737051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:770503-771002 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:791462-792661 Neighboring gene dynein axonemal assembly factor 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:807142-808341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:821444-822643 Neighboring gene uncharacterized LOC124901567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:837226-837726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:849762-850262 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:850239-850399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:852706-853270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:853271-853834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:855273-856014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17821 Neighboring gene Sharpr-MPRA regulatory region 7003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:869831-870726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25474 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:871666-872865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25475 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene uncharacterized LOC124901568

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
Tat tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP-dependent protein kinase regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cAMP-dependent protein kinase complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in ciliary base TAS
Traceable Author Statement
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase type I-beta regulatory subunit
Names
protein kinase, cAMP-dependent, regulatory subunit type I beta
protein kinase, cAMP-dependent, regulatory, type I, beta
NP_001158230.1
NP_001158231.1
NP_001158232.1
NP_001158233.1
NP_001158234.1
NP_002726.1
XP_011513748.1
XP_047276563.1
XP_047276564.1
XP_047276565.1
XP_047276566.1
XP_054214610.1
XP_054214611.1
XP_054214612.1
XP_054214613.1
XP_054214614.1
XP_054214615.1
XP_054214616.1
XP_054214617.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042811.1 RefSeqGene

    Range
    5396..183479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164758.2NP_001158230.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA910871
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
    Related
    ENSP00000385349.1, ENST00000403562.5
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. NM_001164759.1NP_001158231.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA210679
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. NM_001164760.2NP_001158232.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, CT003793
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
    Related
    ENSP00000440449.1, ENST00000537384.6
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. NM_001164761.2NP_001158233.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158233.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA162030
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
    Related
    ENSP00000385749.1, ENST00000406797.5
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  5. NM_001164762.2NP_001158234.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158234.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA501689
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
    Related
    ENSP00000444487.1, ENST00000544935.5
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  6. NM_002735.3NP_002726.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_002726.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DC314672
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
    Related
    ENSP00000353415.4, ENST00000360274.8
    Conserved Domains (2) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    549197..728934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420607.1XP_047276563.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
  2. XM_047420608.1XP_047276564.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
  3. XM_011515446.3XP_011513748.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X2

    UniProtKB/TrEMBL
    A8K099, B4DM81
    Conserved Domains (2) summary
    COG0664
    Location:194304
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:200315
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. XM_047420609.1XP_047276565.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

    UniProtKB/TrEMBL
    H7BYW5
  5. XM_047420610.1XP_047276566.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

    UniProtKB/TrEMBL
    H7BYW5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    650161..832029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358635.1XP_054214610.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
  2. XM_054358636.1XP_054214611.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    P31321, Q8N422
    UniProtKB/TrEMBL
    A8K099, B4DM81
  3. XM_054358637.1XP_054214612.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X2

    UniProtKB/TrEMBL
    A8K099, B4DM81
  4. XM_054358641.1XP_054214616.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

    UniProtKB/TrEMBL
    H7BYW5
  5. XM_054358642.1XP_054214617.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

    UniProtKB/TrEMBL
    H7BYW5
  6. XM_054358639.1XP_054214614.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X4

    UniProtKB/TrEMBL
    C9JSK5
  7. XM_054358638.1XP_054214613.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X4

    UniProtKB/TrEMBL
    C9JSK5
  8. XM_054358640.1XP_054214615.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X4

    UniProtKB/TrEMBL
    C9JSK5