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PRKAR1B protein kinase cAMP-dependent type I regulatory subunit beta [ Homo sapiens (human) ]

Gene ID: 5575, updated on 1-Aug-2020

Summary

Official Symbol
PRKAR1Bprovided by HGNC
Official Full Name
protein kinase cAMP-dependent type I regulatory subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9390
See related
Ensembl:ENSG00000188191 MIM:176911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKAR1
Summary
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Biased expression in brain (RPKM 53.5), ovary (RPKM 6.9) and 11 other tissues See more
Orthologs

Genomic context

See PRKAR1B in Genome Data Viewer
Location:
7p22.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (549185..727676, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (588834..767313, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8552 Neighboring gene platelet derived growth factor subunit A Neighboring gene heart tissue-associated transcript 92 Neighboring gene PRKAR1B antisense RNA 2 Neighboring gene PRKAR1B antisense RNA 1 Neighboring gene uncharacterized LOC105375119 Neighboring gene dynein axonemal assembly factor 5 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene guided entry of tail-anchored proteins factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
Tat tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase A activity TAS
Traceable Author Statement
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle cycle IEA
Inferred from Electronic Annotation
more info
 
renal water homeostasis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-dependent protein kinase complex NAS
Non-traceable Author Statement
more info
PubMed 
ciliary base TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
multivesicular body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase type I-beta regulatory subunit
Names
protein kinase, cAMP-dependent, regulatory subunit type I beta
protein kinase, cAMP-dependent, regulatory, type I, beta
NP_001158230.1
NP_001158231.1
NP_001158232.1
NP_001158233.1
NP_001158234.1
NP_002726.1
XP_011513748.1
XP_016867922.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042811.1 RefSeqGene

    Range
    5001..183480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164758.1NP_001158230.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA910871
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321
    Related
    ENSP00000385349.1, ENST00000403562.5
    Conserved Domains (3) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. NM_001164759.1NP_001158231.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA210679
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321
    Conserved Domains (3) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. NM_001164760.2NP_001158232.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, CT003793
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321
    Related
    ENSP00000440449.1, ENST00000537384.6
    Conserved Domains (3) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. NM_001164761.1NP_001158233.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158233.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA162030
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321
    Related
    ENSP00000385749.1, ENST00000406797.5
    Conserved Domains (3) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  5. NM_001164762.1NP_001158234.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001158234.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DA501689
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321
    Related
    ENSP00000444487.1, ENST00000544935.5
    Conserved Domains (3) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  6. NM_002735.2NP_002726.1  cAMP-dependent protein kinase type I-beta regulatory subunit

    See identical proteins and their annotated locations for NP_002726.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC147651, BC036828, DC314672
    Consensus CDS
    CCDS34579.1
    UniProtKB/Swiss-Prot
    P31321
    Related
    ENSP00000353415.4, ENST00000360274.8
    Conserved Domains (3) summary
    cd12102
    Location:1164
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    549185..727676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515446.2XP_011513748.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    Conserved Domains (2) summary
    COG0664
    Location:194304
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:200315
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. XM_017012433.1XP_016867922.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X2

    Related
    ENSP00000383569.2, ENST00000400758.6
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