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Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 19082, updated on 9-May-2024

Summary

Official Symbol
Prkag1provided by MGI
Official Full Name
protein kinase, AMP-activated, gamma 1 non-catalytic subunitprovided by MGI
Primary source
MGI:MGI:108411
See related
Ensembl:ENSMUSG00000067713 AllianceGenome:MGI:108411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prkaac
Summary
Predicted to enable several functions, including adenyl ribonucleotide binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to contribute to AMP-activated protein kinase activity. Involved in import into nucleus. Located in nucleus. Is expressed in several structures, including future brain; heart; liver; and nervous system. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 48.6), liver E14 (RPKM 44.9) and 28 other tissues See more
Orthologs
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Genomic context

See Prkag1 in Genome Data Viewer
Location:
15 F1; 15 54.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98710678..98729354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98812797..98831508, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 1 Neighboring gene dendrin Neighboring gene STARR-positive B cell enhancer ABC_E1918 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98663163-98663346 Neighboring gene lysine (K)-specific methyltransferase 2D Neighboring gene STARR-seq mESC enhancer starr_39676 Neighboring gene STARR-positive B cell enhancer ABC_E10880 Neighboring gene Ras homolog enriched in brain like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables AMP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to AMP-activated protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables AMP-activated protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of catalytic activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit gamma-1
Names
AMPK gamma1
AMPK subunit gamma-1
AMPKg

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411575.1NP_001398504.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161165
  2. NM_016781.3NP_058061.2  5'-AMP-activated protein kinase subunit gamma-1 isoform 1

    See identical proteins and their annotated locations for NP_058061.2

    Status: VALIDATED

    Source sequence(s)
    AC161165
    Consensus CDS
    CCDS49724.1
    UniProtKB/Swiss-Prot
    O54950, Q5PRE8
    UniProtKB/TrEMBL
    Q3TWR3
    Related
    ENSMUSP00000132499.2, ENSMUST00000168846.3
    Conserved Domains (2) summary
    cd04618
    Location:45174
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:201320
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98710678..98729354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)