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PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 [ Homo sapiens (human) ]

Gene ID: 5571, updated on 4-May-2020

Summary

Official Symbol
PRKAG1provided by HGNC
Official Full Name
protein kinase AMP-activated non-catalytic subunit gamma 1provided by HGNC
Primary source
HGNC:HGNC:9385
See related
Ensembl:ENSG00000181929 MIM:602742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMPKG
Summary
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 18.1), adrenal (RPKM 16.8) and 25 other tissues See more
Orthologs

Genomic context

See PRKAG1 in Genome Data Viewer
Location:
12q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (49002272..49018975, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49396055..49413012, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369756 Neighboring gene DDN and PRKAG1 antisense RNA 1 Neighboring gene dendrin Neighboring gene lysine methyltransferase 2D Neighboring gene RHEB like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8666

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to AMP-activated protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP-dependent protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
cAMP-dependent protein kinase regulator activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
import into nucleus IEA
Inferred from Electronic Annotation
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of glycolytic process TAS
Traceable Author Statement
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit gamma-1
Names
5'-AMP-activated protein kinase, gamma-1 subunit
AMPK gamma-1 chain
AMPK gamma1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206709.2NP_001193638.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 3

    See identical proteins and their annotated locations for NP_001193638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
    Source sequence(s)
    AK097606, BC000358, BM667691
    Consensus CDS
    CCDS55825.1
    UniProtKB/Swiss-Prot
    P54619
    Related
    ENSP00000323867.5, ENST00000316299.9
    Conserved Domains (3) summary
    COG0517
    Location:212328
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:46184
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:211330
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  2. NM_001206710.2NP_001193639.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 4

    See identical proteins and their annotated locations for NP_001193639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC011603, AK293332, BC000358, BM667691
    Consensus CDS
    CCDS55824.1
    UniProtKB/Swiss-Prot
    P54619
    Related
    ENSP00000448972.1, ENST00000552212.5
    Conserved Domains (2) summary
    cd04618
    Location:6142
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:168291
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
  3. NM_002733.5NP_002724.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 1

    See identical proteins and their annotated locations for NP_002724.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC000358, BM667691, DB020277
    Consensus CDS
    CCDS8777.1
    UniProtKB/Swiss-Prot
    P54619
    UniProtKB/TrEMBL
    A0A024R125
    Related
    ENSP00000447433.1, ENST00000548065.7
    Conserved Domains (2) summary
    cd04618
    Location:46175
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:202321
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    49002272..49018975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269019.4XP_005269076.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X1

    Conserved Domains (3) summary
    COG0517
    Location:240356
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:92212
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:239358
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  2. XM_011538562.2XP_011536864.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X2

    See identical proteins and their annotated locations for XP_011536864.1

    UniProtKB/Swiss-Prot
    P54619
    Conserved Domains (2) summary
    cd04618
    Location:6142
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:168291
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
  3. XM_017019623.1XP_016875112.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X3

    Conserved Domains (3) summary
    COG0517
    Location:119235
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:191
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:118237
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  4. XM_005269020.2XP_005269077.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X3

    Conserved Domains (3) summary
    COG0517
    Location:119235
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:191
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:118237
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  5. XM_017019622.1XP_016875111.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X3

    Conserved Domains (3) summary
    COG0517
    Location:119235
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:191
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:118237
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212461.1: Suppressed sequence

    Description
    NM_212461.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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