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Mob4 MOB family member 4, phocein [ Mus musculus (house mouse) ]

Gene ID: 19070, updated on 30-Apr-2024

Summary

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Official Symbol
Mob4provided by MGI
Official Full Name
MOB family member 4, phoceinprovided by MGI
Primary source
MGI:MGI:104899
See related
Ensembl:ENSMUSG00000025979 AllianceGenome:MGI:104899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phocn; Prei3; Mobkl3; 2610109B12Rik
Summary
Predicted to enable kinase binding activity. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human MOB4 (MOB family member 4, phocein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.4), bladder adult (RPKM 17.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Mob4 in Genome Data Viewer
Location:
1 C1.2; 1 28.03 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55170404..55194058)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55131245..55154899)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:55187824-55188011 Neighboring gene serine/arginine repetitive matrix 2 pseudogene Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene raftlin family member 2 Neighboring gene STARR-seq mESC enhancer starr_00949 Neighboring gene STARR-positive B cell enhancer ABC_E11071 Neighboring gene predicted gene 10561

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. Moreno CS, et al. J Biol Chem, 2001 Jun 29. PMID 11319234, Free PMC Article
  2. Expression patterns of novel genes during mouse preimplantation embryogenesis. Temeles GL, et al. Mol Reprod Dev, 1994 Feb. PMID 7545925
  3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MOB-like protein phocein
Names
MOB1, Mps One Binder kinase activator-like 3
class II mMOB1
mob1 homolog 3
mob3
mps one binder kinase activator-like 3
preimplantation protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310585.1 → NP_001297514.1  MOB-like protein phocein isoform 2

    See identical proteins and their annotated locations for NP_001297514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC052475, BE333014, BY128391
    Consensus CDS
    CCDS78585.1
    UniProtKB/TrEMBL
    E0CXA9, Q3UGM5
    Related
    ENSMUSP00000124790.2, ENSMUST00000159311.8
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 186
    Mob1_phocein; Mob1/phocein family

  2. NM_025283.3 → NP_079559.2  MOB-like protein phocein isoform 1

    See identical proteins and their annotated locations for NP_079559.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC052475, BY768556
    Consensus CDS
    CCDS14960.1
    UniProtKB/Swiss-Prot
    Q3TS21, Q6PEB6, Q8BSA3, Q9CX28
    UniProtKB/TrEMBL
    Q3UGM5
    Related
    ENSMUSP00000125415.2, ENSMUST00000162364.8
    Conserved Domains (1) summary
    pfam03637
    Location:53 → 207
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    55170404..55194058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEB6.1 GenPept UniProtKB/Swiss-Prot:Q6PEB6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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