Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp2caprovided by MGI
Official Full Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformprovided by MGI
Primary source: MGI:MGI:1321159
See related: Ensembl:ENSMUSG00000020349 AllianceGenome:MGI:1321159
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP2A
Summary: Enables GABA receptor binding activity and protein serine/threonine phosphatase activity. Involved in T cell homeostasis; negative regulation of glycolytic process through fructose-6-phosphate; and regulation of intracellular signal transduction. Acts upstream of or within mesoderm development. Located in chromosome, centromeric region; cytosol; and plasma membrane. Part of protein phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in CNS E14 (RPKM 132.5), CNS E18 (RPKM 128.8) and 28 other tissues See more
Orthologs: all
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Genomic context

Location:: 11 B1.3; 11 31.86 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (51989651..52013576)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (52098824..52122749)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PP2A regulator IER5L supports prostate cancer progression.
Title: The PP2A regulator IER5L supports prostate cancer progression.
Protein phosphatase 2A propels follicular T helper cell development in lupus.
Title: Protein phosphatase 2A propels follicular T helper cell development in lupus.
The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner.
Title: The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner.
ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response.
Title: ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response.
Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Influences the Meiosis Initiation During Spermatocyte Meiosis Prophase I.
Title: Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Influences the Meiosis Initiation During Spermatocyte Meiosis Prophase I.
Liver PP2A-Calpha Protects From Parenteral Nutrition-associated Hepatic Steatosis.
Title: Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis.
PP2Acalpha regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Title: PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis.
Title: Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis.
PP2A Catalytic Subunit alpha promotes fibroblast activation and kidney fibrosis via ERK pathway.
Title: PP2A Catalytic Subunit α promotes fibroblast activation and kidney fibrosis via ERK pathway.
NXNL1 negatively regulates osteoblast differentiation via GDF15-induced PP2A Calpha dependent manner in MC3T3-E1 cells.
Title: NXNL1 negatively regulates osteoblast differentiation via GDF15-induced PP2A Cα dependent manner in MC3T3-E1 cells.

Submit: New GeneRIF Correction See all GeneRIFs (119)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127380 (e-PCR)
- UniSTS:210690

Ppp2ca (e-PCR), detects polymorphism
- UniSTS:526870

Ppp2ca (e-PCR), detects polymorphism
- UniSTS:526871

PMC22838P1 (e-PCR)
- UniSTS:272153

D5S2786 (e-PCR)
- UniSTS:473854

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GABA receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-2 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info	PubMed
contributes_to phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase B binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II transcription initiation surveillance	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II transcription initiation surveillance	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II transcription initiation surveillance	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process through fructose-6-phosphate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IEA Inferred from Electronic Annotation more info
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of INTAC complex	IEA Inferred from Electronic Annotation more info
part_of INTAC complex	ISO Inferred from Sequence Orthology more info
part_of INTAC complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in chromatin	IEA Inferred from Electronic Annotation more info
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
part_of integrator complex	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein serine/threonine phosphatase complex	IEA Inferred from Electronic Annotation more info
part_of protein serine/threonine phosphatase complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Names: PP2A-alpha

NP_062284.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019411.4 → NP_062284.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

See identical proteins and their annotated locations for NP_062284.1

Status: VALIDATED

Source sequence(s)

AL935177

Consensus CDS

CCDS24666.1

UniProtKB/Swiss-Prot

O88591, P13353, P63330, Q5SNY5

UniProtKB/TrEMBL

Q8BN07

Related

ENSMUSP00000020608.3, ENSMUST00000020608.3

Conserved Domains (1) summary

cd07415
Location:9 → 293

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain