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Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [ Mus musculus (house mouse) ]

Gene ID: 19052, updated on 7-Apr-2019

Summary

Official Symbol
Ppp2caprovided by MGI
Official Full Name
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformprovided by MGI
Primary source
MGI:MGI:1321159
See related
Ensembl:ENSMUSG00000020349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP2A; R75353
Expression
Ubiquitous expression in CNS E14 (RPKM 132.5), CNS E18 (RPKM 128.8) and 28 other tissues See more
Orthologs

Genomic context

See Ppp2ca in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (52098824..52122749)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51912326..51936251)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene cyclin-dependent kinase-like 3 Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061 Neighboring gene olfactory receptor 1373

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GABA receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein antigen binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microtubule binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein heterotrimerization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
response to lead ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Names
PP2A-alpha
protein phosphatase 2a, catalytic subunit, alpha isoform
NP_062284.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019411.4NP_062284.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

    See identical proteins and their annotated locations for NP_062284.1

    Status: VALIDATED

    Source sequence(s)
    AL935177
    Consensus CDS
    CCDS24666.1
    UniProtKB/Swiss-Prot
    P63330
    Related
    ENSMUSP00000020608.2, ENSMUST00000020608.2
    Conserved Domains (1) summary
    cd07415
    Location:9293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    52098824..52122749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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