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PPP2CA protein phosphatase 2 catalytic subunit alpha [ Homo sapiens (human) ]

Gene ID: 5515, updated on 3-May-2020

Summary

Official Symbol
PPP2CAprovided by HGNC
Official Full Name
protein phosphatase 2 catalytic subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:9299
See related
Ensembl:ENSG00000113575 MIM:176915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha
Summary
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 63.8), bone marrow (RPKM 57.1) and 25 other tissues See more
Orthologs

Genomic context

See PPP2CA in Genome Data Viewer
Location:
5q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (134194332..134226073, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133532148..133561950, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transcription factor 7 Neighboring gene S-phase kinase associated protein 1 Neighboring gene microRNA 3661 Neighboring gene cyclin dependent kinase like 3 Neighboring gene ribosomal protein S13 pseudogene 6 Neighboring gene ubiquitin conjugating enzyme E2 B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of PPP2CA is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
Vpu vpu IFN-alpha and IFN-beta increases SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA receptor binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
ceramide metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
inactivation of MAPK activity NAS
Non-traceable Author Statement
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mesoderm development IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear envelope reassembly TAS
Traceable Author Statement
more info
 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tyrosine phosphorylation of STAT protein NAS
Non-traceable Author Statement
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
peptidyl-serine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of microtubule binding NAS
Non-traceable Author Statement
more info
PubMed 
regulation of protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
response to lead ion ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lead ion TAS
Traceable Author Statement
more info
PubMed 
response to organic substance NAS
Non-traceable Author Statement
more info
PubMed 
second-messenger-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex TAS
Traceable Author Statement
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Names
PP2A-alpha
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
protein phosphatase 2, catalytic subunit, alpha isozyme
replication protein C
serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
NP_001341948.1
NP_002706.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046997.1 RefSeqGene

    Range
    5001..35008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355019.1NP_001341948.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC104109
    Conserved Domains (1) summary
    cd07415
    Location:1228
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. NM_002715.4NP_002706.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_002706.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104109, AK097599
    Consensus CDS
    CCDS4173.1
    UniProtKB/Swiss-Prot
    P67775
    UniProtKB/TrEMBL
    B3KUN1
    Related
    ENSP00000418447.1, ENST00000481195.6
    Conserved Domains (1) summary
    cd07415
    Location:9293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RNA

  1. NR_149151.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' end and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104109

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    134194332..134226073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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