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Ppp1ca protein phosphatase 1 catalytic subunit alpha [ Mus musculus (house mouse) ]

Gene ID: 19045, updated on 27-Feb-2024

Summary

Official Symbol
Ppp1caprovided by MGI
Official Full Name
protein phosphatase 1 catalytic subunit alphaprovided by MGI
Primary source
MGI:MGI:103016
See related
Ensembl:ENSMUSG00000040385 AllianceGenome:MGI:103016
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppp1c; dism2
Summary
Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression and entrainment of circadian clock by photoperiod. Acts upstream of or within several processes, including branching morphogenesis of an epithelial tube; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and protein dephosphorylation. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including esophagus; eye; and respiratory system. Orthologous to human PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 214.7), genital fat pad adult (RPKM 187.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ppp1ca in Genome Data Viewer
Location:
19 A; 19 3.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4242173..4245418)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4192174..4195419)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene carnosine synthase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4184956-4185264 Neighboring gene TBC1 domain family, member 10c Neighboring gene STARR-positive B cell enhancer ABC_E11010 Neighboring gene STARR-positive B cell enhancer ABC_E4257 Neighboring gene RAD9 checkpoint clamp component A Neighboring gene uncharacterized LOC102631992 Neighboring gene predicted gene, 30082 Neighboring gene STARR-positive B cell enhancer ABC_E11667 Neighboring gene predicted gene, 45928 Neighboring gene cardiotrophin-like cytokine factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding involved in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycogen metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation TAS
Traceable Author Statement
more info
PubMed 
involved_in response to lead ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glycogen granule ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Names
PP-1A
NP_114074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031868.2NP_114074.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit

    See identical proteins and their annotated locations for NP_114074.1

    Status: PROVISIONAL

    Source sequence(s)
    AC140073
    Consensus CDS
    CCDS29421.1
    UniProtKB/Swiss-Prot
    P62137, Q3U7G7, Q9Z1G2
    UniProtKB/TrEMBL
    Q3U8W0
    Related
    ENSMUSP00000039109.5, ENSMUST00000046094.6
    Conserved Domains (2) summary
    PTZ00480
    Location:6308
    PTZ00480; serine/threonine-protein phosphatase; Provisional
    cd07414
    Location:8298
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4242173..4245418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)