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PPP1CA protein phosphatase 1 catalytic subunit alpha [ Homo sapiens (human) ]

Gene ID: 5499, updated on 20-Sep-2020

Summary

Official Symbol
PPP1CAprovided by HGNC
Official Full Name
protein phosphatase 1 catalytic subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:9281
See related
Ensembl:ENSG00000172531 MIM:176875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP1A; PP-1A; PPP1A; PP1alpha
Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Expression
Ubiquitous expression in lymph node (RPKM 67.2), colon (RPKM 56.9) and 25 other tissues See more
Orthologs

Genomic context

See PPP1CA in Genome Data Viewer
Location:
11q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67398183..67401858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67165652..67169376, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130987 Neighboring gene cardiotrophin like cytokine factor 1 Neighboring gene RNA, U6 small nuclear 1238, pseudogene Neighboring gene RAD9 checkpoint clamp component A Neighboring gene TBC1 domain family member 10C Neighboring gene carnosine synthase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Protein phosphatase 1, catalytic subunit, alpha isoform (PPP1CA) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat Small molecular compounds prevent the interaction of HIV-1 Tat with protein phosphatase-1 (PP1) and the shuttling of PP1 to the nucleus PubMed
tat PP1 interacts with Tat in part through the binding of Val(36) and Phe(38) of Tat to PP1, and Tat is involved in the nuclear and subnuclear targeting of PP1 PubMed
tat Expression of HIV-1 Tat upregulates the abundance of protein phosphatase 1, catalytic subunit, alpha isoform (PPP1CA) in the nucleoli of Jurkat T-cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat Stimulation of HIV-1 Tat transactivation by protein phosphatase 1 (PP1) is inhibited by nuclear inhibitor of PP1 (NIPP1), indicating Tat function is regulated by PP1/NIPP1 PubMed
tat Protein phosphatase 1 (PP1) associates with HIV-1 Tat and stimulates Tat-mediated transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1674, MGC15877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding involved in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
beta-catenin destruction complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-threonine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation by eIF2 alpha dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lead ion ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PTW/PP1 phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glycogen granule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase type 1 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Names
protein phosphatase 1, catalytic subunit, alpha isozyme
serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
testicular tissue protein Li 155
NP_001008709.1
NP_002699.1
NP_996756.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008709.2NP_001008709.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3

    See identical proteins and their annotated locations for NP_001008709.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also called PP-1 alpha 2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is longer compared to isoform 1.
    Source sequence(s)
    AL557336, BC001888, S57501
    Consensus CDS
    CCDS31618.1
    UniProtKB/Swiss-Prot
    P62136
    UniProtKB/TrEMBL
    A0A140VJS9
    Related
    ENSP00000326031.7, ENST00000312989.11
    Conserved Domains (2) summary
    PTZ00480
    Location:6319
    PTZ00480; serine/threonine-protein phosphatase; Provisional
    cd07414
    Location:8309
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
  2. NM_002708.4NP_002699.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_002699.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    BC001888, BC008010, BE793459
    Consensus CDS
    CCDS8160.1
    UniProtKB/Swiss-Prot
    P62136
    Related
    ENSP00000365936.4, ENST00000376745.9
    Conserved Domains (1) summary
    cd07414
    Location:8298
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
  3. NM_206873.2NP_996756.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2

    See identical proteins and their annotated locations for NP_996756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    BC008010, BE278068, BG480286, BM799599
    Consensus CDS
    CCDS8161.1
    UniProtKB/Swiss-Prot
    P62136
    Related
    ENSP00000350974.4, ENST00000358239.8
    Conserved Domains (1) summary
    cd07414
    Location:19254
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67398183..67401858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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