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Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 19017, updated on 27-Feb-2024

Summary

Official Symbol
Ppargc1aprovided by MGI
Official Full Name
peroxisome proliferative activated receptor, gamma, coactivator 1 alphaprovided by MGI
Primary source
MGI:MGI:1342774
See related
Ensembl:ENSMUSG00000029167 AllianceGenome:MGI:1342774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha
Summary
This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in heart adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 22 other tissues See more
Orthologs
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Genomic context

See Ppargc1a in Genome Data Viewer
Location:
5 C1; 5 27.02 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (51611591..52273316, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (51454249..52115853, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13045 Neighboring gene adaptor protein complex AP-2, alpha 2 subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_13047 Neighboring gene STARR-seq mESC enhancer starr_13049 Neighboring gene predicted gene, 29924 Neighboring gene STARR-seq mESC enhancer starr_13050 Neighboring gene STARR-seq mESC enhancer starr_13051 Neighboring gene predicted gene 42614 Neighboring gene STARR-seq mESC enhancer starr_13052 Neighboring gene STARR-seq mESC enhancer starr_13053 Neighboring gene STARR-seq mESC enhancer starr_13054 Neighboring gene STARR-seq mESC enhancer starr_13055 Neighboring gene STARR-seq mESC enhancer starr_13057 Neighboring gene predicted gene, 40302 Neighboring gene microRNA 6417 Neighboring gene DEAH-box helicase 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of podocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of progesterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within respiratory electron transport chain IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to dietary excess IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to muscle activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to muscle activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Names
PPAR-gamma coactivator 1-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402987.1NP_001389916.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b

    Status: REVIEWED

    Source sequence(s)
    AC111037, AC116763
  2. NM_001402988.1NP_001389917.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform c

    Status: REVIEWED

    Source sequence(s)
    AC111037, AC116763, AC158149
    UniProtKB/TrEMBL
    A0A0G2JGG3
  3. NM_001402989.1NP_001389918.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform d

    Status: REVIEWED

    Source sequence(s)
    AC116763
    UniProtKB/TrEMBL
    A0A0G2JGG3
  4. NM_001402990.1NP_001389919.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

    Status: REVIEWED

    Source sequence(s)
    AC116763, AC163408
  5. NM_001402991.1NP_001389920.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

    Status: REVIEWED

    Source sequence(s)
    AC116763
  6. NM_008904.3NP_032930.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a

    See identical proteins and their annotated locations for NP_032930.1

    Status: REVIEWED

    Source sequence(s)
    AC116763
    Consensus CDS
    CCDS19282.1
    UniProtKB/Swiss-Prot
    L0AM20, L0AN96, L0APB0, O70343, Q3UP72
    UniProtKB/TrEMBL
    A0A0G2JGG3
    Related
    ENSMUSP00000117040.2, ENSMUST00000132734.8
    Conserved Domains (1) summary
    cd12623
    Location:674764
    RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins

RNA

  1. NR_027710.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC116763
  2. NR_132764.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC116763, BB853729, JX866948
  3. NR_175325.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC111037, AC116763, AC158149
  4. NR_175326.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC116763
  5. NR_175327.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC116763

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    51611591..52273316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503775.2XP_006503838.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2

    UniProtKB/TrEMBL
    A0A0G2JGG3
    Conserved Domains (1) summary
    cd12623
    Location:670760
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  2. XM_036164894.1XP_036020787.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

    Conserved Domains (1) summary
    cd12623
    Location:674764
    RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  3. XM_017320718.3XP_017176207.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

    Conserved Domains (1) summary
    cd12623
    Location:549639
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  4. XM_030254205.2XP_030110065.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

    Conserved Domains (1) summary
    cd12623
    Location:549639
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins