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PPARGC1A PPARG coactivator 1 alpha [ Homo sapiens (human) ]

Gene ID: 10891, updated on 3-Dec-2022

Summary

Official Symbol
PPARGC1Aprovided by HGNC
Official Full Name
PPARG coactivator 1 alphaprovided by HGNC
Primary source
HGNC:HGNC:9237
See related
Ensembl:ENSG00000109819 MIM:604517; AllianceGenome:HGNC:9237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha)
Summary
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 8.0), liver (RPKM 6.2) and 15 other tissues See more
Orthologs
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Genomic context

See PPARGC1A in Genome Data Viewer
Location:
4p15.2
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (23792021..24472905, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (23773791..24454625, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (23793644..24474528, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374528 Neighboring gene uncharacterized LOC124900680 Neighboring gene uncharacterized LOC105374527 Neighboring gene VISTA enhancer hs2346 Neighboring gene Sharpr-MPRA regulatory region 9076 Neighboring gene Sharpr-MPRA regulatory region 2780 Neighboring gene Sharpr-MPRA regulatory region 10171 Neighboring gene uncharacterized LOC124900679 Neighboring gene uncharacterized LOC124900678 Neighboring gene uncharacterized LOC124900681 Neighboring gene microRNA 573

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coregulator activity TAS
Traceable Author Statement
more info
PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
PubMed 
involved_in adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in brown fat cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular glucose homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular respiration TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in digestion TAS
Traceable Author Statement
more info
PubMed 
involved_in energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid oxidation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mRNA processing TAS
Traceable Author Statement
more info
PubMed 
involved_in mitochondrion organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ATP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of fatty acid oxidation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gluconeogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of histone acetylation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitochondrial DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization TAS
Traceable Author Statement
more info
PubMed 
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in respiratory electron transport chain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
involved_in response to muscle activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to starvation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in temperature homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in transcription initiation at RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Names
L-PGC-1alpha
PGC-1-alpha
PPAR gamma coactivator variant form
PPARAGCIalpha
PPARGC-1-alpha
PPARgamma coactivator 1alpha
ligand effect modulator-6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028250.2 RefSeqGene

    Range
    587929..685955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330751.2NP_001317680.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 5, encodes the longest isoform (1).
    Source sequence(s)
    AC092834, AC115110, AF186379, BM976883, JQ772116, JQ772117
    UniProtKB/Swiss-Prot
    Q9UBK2
    Conserved Domains (3) summary
    cd12623
    Location:680770
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam09756
    Location:643680
    DDRGK; DDRGK domain
    pfam14621
    Location:257384
    RFX5_DNA_bdg; RFX5 DNA-binding domain
  2. NM_001330752.2NP_001317681.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and contains an alternate exon in its 5' coding region. This variant represents translation initiation at an alternate start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the alternate start codon to encode an isoform (3) that has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC092834, AC115110, AF186379, BM976883, JQ772116
    UniProtKB/Swiss-Prot
    Q9UBK2
  3. NM_001330753.2NP_001317682.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1. Variants 4 and 6 both encode the same isoform (4).
    Source sequence(s)
    AC092834, AF186379, BM976883, HQ695733
    Consensus CDS
    CCDS87211.1
    UniProtKB/Swiss-Prot
    Q9UBK2
    Related
    ENSP00000481498.1, ENST00000613098.4
    Conserved Domains (3) summary
    pfam09756
    Location:511548
    DDRGK; DDRGK domain
    pfam14621
    Location:125252
    RFX5_DNA_bdg; RFX5 DNA-binding domain
    cl17169
    Location:548638
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_001354825.2NP_001341754.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC006229, AC092834, AC115110
    Conserved Domains (3) summary
    cd12623
    Location:680770
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam09756
    Location:643680
    DDRGK; DDRGK domain
    pfam14621
    Location:257384
    RFX5_DNA_bdg; RFX5 DNA-binding domain
  5. NM_001354826.2NP_001341755.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 4, encodes isoform 4.
    Source sequence(s)
    AC092834, AC092846, AC115110
    Consensus CDS
    CCDS87211.1
    Conserved Domains (3) summary
    pfam09756
    Location:511548
    DDRGK; DDRGK domain
    pfam14621
    Location:125252
    RFX5_DNA_bdg; RFX5 DNA-binding domain
    cl17169
    Location:548638
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. NM_001354827.2NP_001341756.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006229, AC092834, AC115110
    Conserved Domains (3) summary
    pfam09756
    Location:643680
    DDRGK; DDRGK domain
    pfam14621
    Location:257384
    RFX5_DNA_bdg; RFX5 DNA-binding domain
    cl17169
    Location:680768
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. NM_001354828.2NP_001341757.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC092834, BX282397
    Consensus CDS
    CCDS87212.1
    UniProtKB/TrEMBL
    D6RBF3
    Related
    ENSP00000424181.1, ENST00000507380.1
  8. NM_013261.5NP_037393.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 2

    See identical proteins and their annotated locations for NP_037393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC092834, AF106698, AF186379, BM976883
    Consensus CDS
    CCDS3429.1
    UniProtKB/Swiss-Prot
    Q9UBK2, Q9UN32
    UniProtKB/TrEMBL
    A0A024R9Q9
    Related
    ENSP00000264867.2, ENST00000264867.7
    Conserved Domains (2) summary
    PHA03420
    Location:200295
    PHA03420; E4 protein; Provisional
    cd12623
    Location:675765
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins

RNA

  1. NR_148981.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092834, AC092846, AC115110
  2. NR_148982.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006229, AC092834, AC115110
  3. NR_148983.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092834, AC092846, AC115110
  4. NR_148984.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092834
  5. NR_148985.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092834, AC115110, JQ772118
  6. NR_148986.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092834, AC115110, JQ772119
  7. NR_148987.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092834, AC115110, JQ772120

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    23792021..24472905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449546.1XP_047305502.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3

  2. XM_047449553.1XP_047305509.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X9

  3. XM_005248134.5XP_005248191.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

    Conserved Domains (1) summary
    pfam12848
    Location:642677
    ABC_tran_Xtn; ABC transporter
  4. XM_005248132.1XP_005248189.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2

    Conserved Domains (2) summary
    PHA03420
    Location:197292
    PHA03420; E4 protein; Provisional
    cd12623
    Location:672762
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  5. XM_047449551.1XP_047305507.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

  6. XM_005248131.6XP_005248188.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1

    Conserved Domains (2) summary
    PHA03420
    Location:204299
    PHA03420; E4 protein; Provisional
    cd12623
    Location:679769
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  7. XM_047449548.1XP_047305504.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4

  8. XM_011513771.2XP_011512073.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X9

    See identical proteins and their annotated locations for XP_011512073.1

    UniProtKB/Swiss-Prot
    Q9UBK2
    Conserved Domains (3) summary
    pfam09756
    Location:511548
    DDRGK; DDRGK domain
    pfam14621
    Location:125252
    RFX5_DNA_bdg; RFX5 DNA-binding domain
    cl17169
    Location:548638
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. XM_011513768.2XP_011512070.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4

    See identical proteins and their annotated locations for XP_011512070.1

    Conserved Domains (1) summary
    cd12623
    Location:640730
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  10. XM_047449550.1XP_047305506.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4

  11. XM_047449549.1XP_047305505.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4

  12. XM_047449547.1XP_047305503.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4

  13. XM_011513769.3XP_011512071.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X7

    Conserved Domains (1) summary
    pfam14621
    Location:257384
    RFX5_DNA_bdg; RFX5 DNA-binding domain
  14. XM_047449552.1XP_047305508.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    23773791..24454625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)