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S1PR1 sphingosine-1-phosphate receptor 1 [ Homo sapiens (human) ]

Gene ID: 1901, updated on 12-Aug-2018

Summary

Official Symbol
S1PR1provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 1provided by HGNC
Primary source
HGNC:HGNC:3165
See related
Ensembl:ENSG00000170989 MIM:601974; Vega:OTTHUMG00000010835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362
Summary
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues See more
Orthologs

Genomic context

See S1PR1 in Genome Data Viewer
Location:
1p21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (101236749..101241520)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101702305..101707076)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928334 Neighboring gene uncharacterized LOC101928370 Neighboring gene ribosomal protein S20 pseudogene 6 Neighboring gene peptidylprolyl isomerase A pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of sphingosine-1-phosphate receptor 1 (S1PR1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
G-protein coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sphingolipid binding IEA
Inferred from Electronic Annotation
more info
 
sphingosine-1-phosphate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle tissue growth involved in heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
heart trabecula morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
sphingosine-1-phosphate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endosome IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 1
Names
S1P receptor 1
S1P receptor Edg-1
endothelial differentiation G-protein coupled receptor 1
endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
sphingosine 1-phosphate receptor EDG1
sphingosine 1-phosphate receptor Edg-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016181.1 RefSeqGene

    Range
    5001..9772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320730.1NP_001307659.1  sphingosine 1-phosphate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL109741, BP236900
    Consensus CDS
    CCDS777.1
    UniProtKB/Swiss-Prot
    P21453
    Conserved Domains (1) summary
    cd15346
    Location:46322
    7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001400.4NP_001391.2  sphingosine 1-phosphate receptor 1

    See identical proteins and their annotated locations for NP_001391.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC018650, CR977007, DB132417, DB572979
    Consensus CDS
    CCDS777.1
    UniProtKB/Swiss-Prot
    P21453
    Related
    ENSP00000305416.6, OTTHUMP00000012525, ENST00000305352.6, OTTHUMT00000029908
    Conserved Domains (1) summary
    cd15346
    Location:46322
    7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    101236749..101241520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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