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Pou3f1 POU domain, class 3, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18991, updated on 8-Feb-2024

Summary

Official Symbol
Pou3f1provided by MGI
Official Full Name
POU domain, class 3, transcription factor 1provided by MGI
Primary source
MGI:MGI:101896
See related
Ensembl:ENSMUSG00000090125 AllianceGenome:MGI:101896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oct6; Otf6; Scip; Tst1; Oct-6; Otf-6; Test1; Tst-1
Summary
Enables DNA binding activity. Involved in positive regulation of gene expression and positive regulation of transcription, DNA-templated. Acts upstream of or within forebrain development; keratinocyte differentiation; and myelination in peripheral nervous system. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; sensory organ; and urinary system. Orthologous to human POU3F1 (POU class 3 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Pou3f1 in Genome Data Viewer
Location:
4 D2.2; 4 57.86 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124551439..124554448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124657646..124660655)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700057H15 gene Neighboring gene STARR-seq mESC enhancer starr_11330 Neighboring gene predicted gene, 31769 Neighboring gene predicted gene 2164 Neighboring gene RIKEN cDNA 4933407E24 gene Neighboring gene STARR-seq mESC enhancer starr_11334 Neighboring gene predicted gene, 38545 Neighboring gene STARR-positive B cell enhancer ABC_E6213 Neighboring gene UTP11 small subunit processome component

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epidermis development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination in peripheral nervous system IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
POU domain, class 3, transcription factor 1
Names
POU domain transcription factor SCIP
octamer binding factor oct6
octamer-binding protein 6
octamer-binding transcription factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011141.2NP_035271.1  POU domain, class 3, transcription factor 1

    See identical proteins and their annotated locations for NP_035271.1

    Status: VALIDATED

    Source sequence(s)
    AK139418, CX242707, X57482
    Consensus CDS
    CCDS57296.1
    UniProtKB/Swiss-Prot
    P21952
    Related
    ENSMUSP00000137374.2, ENSMUST00000053491.9
    Conserved Domains (2) summary
    smart00352
    Location:245319
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:340393
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124551439..124554448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)