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POU3F1 POU class 3 homeobox 1 [ Homo sapiens (human) ]

Gene ID: 5453, updated on 13-Mar-2020

Summary

Official Symbol
POU3F1provided by HGNC
Official Full Name
POU class 3 homeobox 1provided by HGNC
Primary source
HGNC:HGNC:9214
See related
Ensembl:ENSG00000185668 MIM:602479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCT6; OTF6; SCIP
Orthologs

Genomic context

See POU3F1 in Genome Data Viewer
Location:
1p34.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (38043829..38046793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38509523..38512450, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene UTP11 small subunit processome component Neighboring gene Sharpr-MPRA regulatory region 3132 Neighboring gene translation initiation factor IF-2-like Neighboring gene MIR3659 host gene Neighboring gene VISTA enhancer hs238 Neighboring gene microRNA 3659

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
axon ensheathment TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
POU domain, class 3, transcription factor 1
Names
OTF-6
POU domain transcription factor SCIP
octamer-binding protein 6
octamer-binding transcription factor 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002699.4NP_002690.3  POU domain, class 3, transcription factor 1

    See identical proteins and their annotated locations for NP_002690.3

    Status: VALIDATED

    Source sequence(s)
    AL139158
    Consensus CDS
    CCDS30679.1
    UniProtKB/Swiss-Prot
    Q03052
    Related
    ENSP00000362103.2, ENST00000373012.5
    Conserved Domains (2) summary
    smart00352
    Location:247321
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:342395
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    38043829..38046793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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