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T25B9.5 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 188883, updated on 18-Sep-2024

Summary

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Official Symbol
T25B9.5
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00012011
Locus tag
CELE_T25B9.5
See related
AllianceGenome:WB:WBGene00012011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See T25B9.5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (10752359..10754785, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cystatin domain-containing protein Neighboring gene Aminotransferase class I/classII domain-containing protein Neighboring gene Serine/threonine-protein phosphatase Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase
NP_001293881.1
  • Confirmed by transcript evidence
NP_501993.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10752359..10754785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306952.2 → NP_001293881.1  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293881.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ADQ6
    Conserved Domains (3) summary
    smart00221
    Location:180 → 436
    STYKc; Protein kinase; unclassified specificity
    smart00252
    Location:77 → 158
    SH2; Src homology 2 domains
    cd00192
    Location:184 → 437
    PTKc; Catalytic domain of Protein Tyrosine Kinases

  2. NM_069592.2 → NP_501993.1  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501993.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22766
    Conserved Domains (3) summary
    smart00221
    Location:175 → 431
    STYKc; Protein kinase; unclassified specificity
    smart00252
    Location:72 → 153
    SH2; Src homology 2 domains
    cd00192
    Location:179 → 432
    PTKc; Catalytic domain of Protein Tyrosine Kinases
Nucleotide Protein
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