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Plxna2 plexin A2 [ Mus musculus (house mouse) ]

Gene ID: 18845, updated on 16-Oct-2021

Summary

Official Symbol
Plxna2provided by MGI
Official Full Name
plexin A2provided by MGI
Primary source
MGI:MGI:107684
See related
Ensembl:ENSMUSG00000026640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OCT; Plxn2; PlexA2; AA589422; AW457381; mKIAA0463; 2810428A13Rik
Expression
Broad expression in CNS E14 (RPKM 20.1), whole brain E14.5 (RPKM 19.4) and 25 other tissues See more
Orthologs
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Genomic context

See Plxna2 in Genome Data Viewer
Location:
1; 1 H6
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194302020..194499177)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (194619791..194816869)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (196446023..196643063)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31988 Neighboring gene predicted gene, 51784 Neighboring gene predicted gene, 46202 Neighboring gene prefoldin subunit 1-like Neighboring gene microRNA 3962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables semaphorin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables semaphorin receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar granule cell precursor tangential migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limb bud formation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neural tube development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within pharyngeal system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somitogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
plexin-A2
Names
plex 2
plexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008882.2NP_032908.2  plexin-A2 precursor

    See identical proteins and their annotated locations for NP_032908.2

    Status: VALIDATED

    Source sequence(s)
    AA289826, AC162447, BC068155, BY753209, D86949
    Consensus CDS
    CCDS35827.1
    UniProtKB/Swiss-Prot
    P70207
    Related
    ENSMUSP00000027952.6, ENSMUST00000027952.12
    Conserved Domains (7) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:9541037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10411141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:806855
    PSI; Plexin repeat
    pfam01833
    Location:11431227
    TIG; IPT/TIG domain
    pfam08337
    Location:13111864
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194302020..194499177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497240.5XP_006497303.1  plexin-A2 isoform X1

    Conserved Domains (9) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:9541037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10411141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:806855
    PSI; Plexin repeat
    pfam01833
    Location:11431227
    TIG; IPT/TIG domain
    pfam08337
    Location:13111870
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:566654
    TIG_plexin; TIG domain
    pfam18020
    Location:708802
    TIG_2; TIG domain found in plexin
  2. XM_036162782.1XP_036018675.1  plexin-A2 isoform X2

    Conserved Domains (4) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    pfam01437
    Location:806855
    PSI; Plexin repeat
    pfam17960
    Location:565654
    TIG_plexin; TIG domain
    pfam18020
    Location:708802
    TIG_2; TIG domain found in plexin

RNA

  1. XR_373891.5 RNA Sequence

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