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Plxna2 plexin A2 [ Mus musculus (house mouse) ]

Gene ID: 18845, updated on 2-Jul-2024

Summary

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Official Symbol
Plxna2provided by MGI
Official Full Name
plexin A2provided by MGI
Primary source
MGI:MGI:107684
See related
Ensembl:ENSMUSG00000026640 AllianceGenome:MGI:107684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OCT; Plxn2; PlexA2; mKIAA0463; 2810428A13Rik
Summary
Enables identical protein binding activity and semaphorin receptor activity. Involved in regulation of cell migration and semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including cerebellar granule cell precursor tangential migration; chordate embryonic development; and limb bud formation. Is integral component of plasma membrane. Is expressed in several structures, including genitourinary system; heart; lung; nervous system; and sensory organ. Orthologous to human PLXNA2 (plexin A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 20.1), whole brain E14.5 (RPKM 19.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Plxna2 in Genome Data Viewer
Location:
1 H6; 1 98.27 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194302020..194499177)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (194619791..194816869)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31988 Neighboring gene predicted gene, 51784 Neighboring gene STARR-seq mESC enhancer starr_03492 Neighboring gene STARR-seq mESC enhancer starr_03493 Neighboring gene STARR-seq mESC enhancer starr_03494 Neighboring gene STARR-seq mESC enhancer starr_03495 Neighboring gene STARR-seq mESC enhancer starr_03496 Neighboring gene STARR-seq mESC enhancer starr_03498 Neighboring gene predicted gene, 46202 Neighboring gene prefoldin subunit 1-like Neighboring gene microRNA 3962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immunoaffinity Purification of the Glycosylated Extracellular Fragment of Mouse Plexin A2 Produced in a Mammalian Expression System. Nogi T, et al. Methods Mol Biol, 2017. PMID 27787842
  2. PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Shim SO, et al. Mol Cell Neurosci, 2012 Jun. PMID 22564823, Free PMC Article
  3. PLXNA2 as a candidate gene in patients with intellectual disability. Altuame FD, et al. Am J Med Genet A, 2021 Dec. PMID 34327814
  4. Time-lapse analysis of tangential migration in Sema6A and PlexinA2 knockouts. Renaud J, et al. Mol Cell Neurosci, 2014 Nov. PMID 25284064
  5. Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A. Rohm B, et al. Mech Dev, 2000 May. PMID 10781943

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLXNA2 as a candidate gene in patients with intellectual disability.
    Title: PLXNA2 as a candidate gene in patients with intellectual disability.
  2. Here, biochemical analysis of NgR1 function uncovered a physical complex with CRMP cytoplasmic mediators, and this led to appreciation of a role for PlexinA2 in concert with NgR1 after adult spinal cord trauma.
    Title: Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.
  3. These findings implicate Semaphorin-6A - Plexin-A2/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium.
    Title: Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.
  4. describe procedures for protein production and purification that we utilized in the crystallographic study of the mouse Plexin A2 (mPlxnA2) extracellular fragment, including the sema domain
    Title: Immunoaffinity Purification of the Glycosylated Extracellular Fragment of Mouse Plexin A2 Produced in a Mammalian Expression System.
  5. work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding.
    Title: Structural Basis for Plexin Activation and Regulation.
  6. Using time-lapse videomicroscopy we provide evidence that Sema6A/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell
    Title: PlexinA2 and Sema6A are required for retinal progenitor cell migration.
  7. Plexin A2 is expressed in both On and Off starburst amacrine cell.
    Title: On and off retinal circuit assembly by divergent molecular mechanisms.
  8. results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling
    Title: PlexinA2 mediates osteoblast differentiation via regulation of Runx2.
  9. crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto)
    Title: Structural basis of semaphorin-plexin signalling.
  10. crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states
    Title: Structural basis for semaphorin signalling through the plexin receptor.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables semaphorin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables semaphorin receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellar granule cell precursor tangential migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in limb bud formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural tube development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in pharyngeal system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in somitogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plexin-A2
Names
plex 2
plexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008882.2 → NP_032908.2  plexin-A2 precursor

    See identical proteins and their annotated locations for NP_032908.2

    Status: VALIDATED

    Source sequence(s)
    AA289826, AC162447, BC068155, BY753209, D86949
    Consensus CDS
    CCDS35827.1
    UniProtKB/Swiss-Prot
    P70207, Q6NVE6, Q6PHN4, Q80TZ7, Q8R1I4
    Related
    ENSMUSP00000027952.6, ENSMUST00000027952.12
    Conserved Domains (7) summary
    cd11272
    Location:38 → 552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:954 → 1037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858 → 953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:1041 → 1141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:806 → 855
    PSI; Plexin repeat
    pfam01833
    Location:1143 → 1227
    TIG; IPT/TIG domain
    pfam08337
    Location:1311 → 1864
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194302020..194499177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497240.5 → XP_006497303.1  plexin-A2 isoform X1

    Conserved Domains (9) summary
    cd11272
    Location:38 → 552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:954 → 1037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858 → 953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:1041 → 1141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:806 → 855
    PSI; Plexin repeat
    pfam01833
    Location:1143 → 1227
    TIG; IPT/TIG domain
    pfam08337
    Location:1311 → 1870
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:566 → 654
    TIG_plexin; TIG domain
    pfam18020
    Location:708 → 802
    TIG_2; TIG domain found in plexin

  2. XM_036162782.1 → XP_036018675.1  plexin-A2 isoform X2

    Conserved Domains (4) summary
    cd11272
    Location:38 → 552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    pfam01437
    Location:806 → 855
    PSI; Plexin repeat
    pfam17960
    Location:565 → 654
    TIG_plexin; TIG domain
    pfam18020
    Location:708 → 802
    TIG_2; TIG domain found in plexin

RNA

  1. XR_373891.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70207.2 GenPept UniProtKB/Swiss-Prot:P70207

Gene LinkOut

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