Format

Send to:

Choose Destination

GPR183 G protein-coupled receptor 183 [ Homo sapiens (human) ]

Gene ID: 1880, updated on 8-Jul-2021

Summary

Official Symbol
GPR183provided by HGNC
Official Full Name
G protein-coupled receptor 183provided by HGNC
Primary source
HGNC:HGNC:3128
See related
Ensembl:ENSG00000169508 MIM:605741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBI2; hEBI2
Summary
This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 44.7), bone marrow (RPKM 34.8) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPR183 in Genome Data Viewer
Location:
13q32.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (99294273..99307399, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99946793..99959653, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene UBA domain containing 2 Neighboring gene H2A.Z histone pseudogene 3 Neighboring gene G protein-coupled receptor 18 Neighboring gene FKSG29 Neighboring gene microRNA 623

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of G protein-coupled receptor 183 (GPR183) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxysterol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxysterol binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T follicular helper cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in humoral immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in leukocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mature B cell differentiation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of astrocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G-protein coupled receptor 183
Names
EBV-induced G-protein coupled receptor 2
Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
epstein-Barr virus-induced G-protein coupled receptor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004951.5NP_004942.1  G-protein coupled receptor 183

    See identical proteins and their annotated locations for NP_004942.1

    Status: REVIEWED

    Source sequence(s)
    AK313443, AW574697, BC020752
    Consensus CDS
    CCDS9492.1
    UniProtKB/Swiss-Prot
    P32249
    UniProtKB/TrEMBL
    A0A024RDX2
    Related
    ENSP00000365596.4, ENST00000376414.5
    Conserved Domains (1) summary
    cd15159
    Location:32319
    7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    99294273..99307399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020405.2XP_016875894.1  G-protein coupled receptor 183 isoform X1

    UniProtKB/Swiss-Prot
    P32249
    UniProtKB/TrEMBL
    A0A024RDX2
    Conserved Domains (1) summary
    cd15159
    Location:32319
    7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Support Center