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Lypla1 lysophospholipase 1 [ Mus musculus (house mouse) ]

Gene ID: 18777, updated on 26-Sep-2022

Summary

Official Symbol
Lypla1provided by MGI
Official Full Name
lysophospholipase 1provided by MGI
Primary source
MGI:MGI:1344588
See related
Ensembl:ENSMUSG00000025903 AllianceGenome:MGI:1344588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APT-1; LPL-I; Pla1a; Gm39587
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Acts upstream of or within negative regulation of Golgi to plasma membrane protein transport. Located in cytosol. Is expressed in several structures, including brain; cardiovascular system; cranium; genitourinary system; and gut. Orthologous to human LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 20.2), placenta adult (RPKM 17.5) and 28 other tissues See more
Orthologs
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Genomic context

See Lypla1 in Genome Data Viewer
Location:
1; 1 A1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4878046..4916958)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4807823..4846735)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase (lipoamide) beta pseudogene Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene uncharacterized LOC118567656 Neighboring gene transcription elongation factor A (SII) 1 Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Tcea1

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity ISO
Inferred from Sequence Orthology
more info
 
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-protein thioesterase 1
Names
lysoPLA I
lysophopholipase 1
lysophospholipase I
palmitoyl-protein hydrolase
phospholipase 1a
NP_001342641.1
NP_032892.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355712.1NP_001342641.1  acyl-protein thioesterase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102311
    Consensus CDS
    CCDS87810.1
    UniProtKB/TrEMBL
    A0A8C6HZP7, D3Z111
    Related
    ENSMUSP00000111191.2, ENSMUST00000115529.8
    Conserved Domains (1) summary
    pfam02230
    Location:11192
    Abhydrolase_2; Phospholipase/Carboxylesterase
  2. NM_008866.3NP_032892.1  acyl-protein thioesterase 1 isoform 1

    See identical proteins and their annotated locations for NP_032892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102311, AK002674, BQ033435
    Consensus CDS
    CCDS14806.1
    UniProtKB/Swiss-Prot
    P97823, Q8BWM6
    UniProtKB/TrEMBL
    A0A8C6HYQ4
    Related
    ENSMUSP00000027036.5, ENSMUST00000027036.11
    Conserved Domains (2) summary
    COG0596
    Location:24155
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam02230
    Location:11226
    Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    4878046..4916958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)