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LYPLA1 lysophospholipase 1 [ Homo sapiens (human) ]

Gene ID: 10434, updated on 7-Dec-2018

Summary

Official Symbol
LYPLA1provided by HGNC
Official Full Name
lysophospholipase 1provided by HGNC
Primary source
HGNC:HGNC:6737
See related
Ensembl:ENSG00000120992 MIM:605599
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APT1; LPL1; APT-1; LPL-I; hAPT1
Summary
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in urinary bladder (RPKM 38.7), testis (RPKM 35.4) and 25 other tissues See more
Orthologs

Genomic context

See LYPLA1 in Genome Data Viewer
Location:
8q11.23
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (54046367..54102017, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54958927..55014577, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) pseudogene Neighboring gene transcription elongation factor A1 Neighboring gene uncharacterized LOC105375839 Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 5 Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene RNA, U6atac small nuclear 32, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lysophospholipase I (LYPLA1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
    Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Choline metabolism in cancer, conserved biosystem (from KEGG)
    Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
    Glycerophospholipid metabolism, organism-specific biosystem
    Glycerophospholipid metabolism
  • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
    Glycerophospholipid metabolism, conserved biosystem
    Glycerophospholipid metabolism
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of nitric oxide, organism-specific biosystem (from REACTOME)
    Metabolism of nitric oxide, organism-specific biosystemNitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blo...
  • eNOS activation, organism-specific biosystem (from REACTOME)
    eNOS activation, organism-specific biosystemeNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localizat...
  • eNOS activation and regulation, organism-specific biosystem (from REACTOME)
    eNOS activation and regulation, organism-specific biosystemOriginally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
lysophospholipase activity TAS
Traceable Author Statement
more info
PubMed 
palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoyl-(protein) hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
palmitoyl-(protein) hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Golgi to plasma membrane protein transport IEA
Inferred from Electronic Annotation
more info
 
protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
acyl-protein thioesterase 1
Names
lysoPLA I
lysophospholipase I
lysophospholipid-specific lysophospholipase
NP_001266285.1
NP_001266286.1
NP_001266287.1
NP_001266288.1
NP_001266289.1
NP_006321.1
XP_005251184.1
XP_016868445.1
XP_016868446.1
XP_016868447.1
XP_016868448.1
XP_016868449.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001279356.1NP_001266285.1  acyl-protein thioesterase 1 isoform 2

    See identical proteins and their annotated locations for NP_001266285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA827237, AF035293, AF052112, AK298206
    Consensus CDS
    CCDS75739.1
    UniProtKB/Swiss-Prot
    O75608
    UniProtKB/TrEMBL
    B4DP64
    Related
    ENSP00000482430.1, ENST00000618914.4
    Conserved Domains (1) summary
    pfam02230
    Location:11192
    Abhydrolase_2; Phospholipase/Carboxylesterase
  2. NM_001279357.1NP_001266286.1  acyl-protein thioesterase 1 isoform 3

    See identical proteins and their annotated locations for NP_001266286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AA827237, AF035293, AF052112, AF077199
    Consensus CDS
    CCDS64899.1
    UniProtKB/Swiss-Prot
    O75608
    Related
    ENSP00000344477.6, ENST00000343231.10
    Conserved Domains (1) summary
    pfam02230
    Location:11210
    Abhydrolase_2; Phospholipase/Carboxylesterase
  3. NM_001279358.1NP_001266287.1  acyl-protein thioesterase 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
    Source sequence(s)
    AA827237, AF035293, AF052112, DA881616
    UniProtKB/Swiss-Prot
    O75608
    Conserved Domains (1) summary
    pfam02230
    Location:11212
    Abhydrolase_2; Phospholipase/Carboxylesterase
  4. NM_001279359.1NP_001266288.1  acyl-protein thioesterase 1 isoform 5

    See identical proteins and their annotated locations for NP_001266288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in its 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA307642, AA827237, AF035293, AF052112
    UniProtKB/Swiss-Prot
    O75608
    Conserved Domains (1) summary
    pfam02230
    Location:8177
    Abhydrolase_2; Phospholipase/Carboxylesterase
  5. NM_001279360.1NP_001266289.1  acyl-protein thioesterase 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA827237, AF035293, DA817192, DA883059
    Consensus CDS
    CCDS75738.1
    UniProtKB/Swiss-Prot
    O75608
    UniProtKB/TrEMBL
    A0A087X1K9
    Related
    ENSP00000484280.1, ENST00000618741.1
    Conserved Domains (1) summary
    pfam02230
    Location:1162
    Abhydrolase_2; Phospholipase/Carboxylesterase
  6. NM_006330.4NP_006321.1  acyl-protein thioesterase 1 isoform 1

    See identical proteins and their annotated locations for NP_006321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA827237, AF035293, AF052112
    Consensus CDS
    CCDS6157.1
    UniProtKB/Swiss-Prot
    O75608
    UniProtKB/TrEMBL
    Q6IAQ1
    Related
    ENSP00000320043.3, ENST00000316963.7
    Conserved Domains (1) summary
    pfam02230
    Location:11226
    Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    54046367..54102017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012959.1XP_016868448.1  acyl-protein thioesterase 1 isoform X4

    UniProtKB/TrEMBL
    A0A087X1K9
    Conserved Domains (1) summary
    pfam02230
    Location:1162
    Abhydrolase_2; Phospholipase/Carboxylesterase
  2. XM_017012958.1XP_016868447.1  acyl-protein thioesterase 1 isoform X3

  3. XM_017012960.1XP_016868449.1  acyl-protein thioesterase 1 isoform X4

    UniProtKB/TrEMBL
    A0A087X1K9
    Conserved Domains (1) summary
    pfam02230
    Location:1162
    Abhydrolase_2; Phospholipase/Carboxylesterase
  4. XM_017012956.2XP_016868445.1  acyl-protein thioesterase 1 isoform X1

  5. XM_017012957.2XP_016868446.1  acyl-protein thioesterase 1 isoform X2

    Conserved Domains (1) summary
    pfam02230
    Location:8177
    Abhydrolase_2; Phospholipase/Carboxylesterase
  6. XM_005251127.5XP_005251184.1  acyl-protein thioesterase 1 isoform X2

    See identical proteins and their annotated locations for XP_005251184.1

    Conserved Domains (1) summary
    pfam02230
    Location:8177
    Abhydrolase_2; Phospholipase/Carboxylesterase

RNA

  1. XR_001745453.1 RNA Sequence

  2. XR_001745454.1 RNA Sequence

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