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Prkci protein kinase C, iota [ Mus musculus (house mouse) ]

Gene ID: 18759, updated on 25-Sep-2018

Summary

Official Symbol
Prkciprovided by MGI
Official Full Name
protein kinase C, iotaprovided by MGI
Primary source
MGI:MGI:99260
See related
Ensembl:ENSMUSG00000037643 Vega:OTTMUSG00000032732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkci; Pkcl; Prkcl; AI427505; PKClambda; mKIAA4165; aPKClambda; 2310021H13Rik
Expression
Ubiquitous expression in bladder adult (RPKM 26.7), placenta adult (RPKM 19.4) and 28 other tissues See more
Orthologs

Genomic context

See Prkci in Genome Data Viewer
Location:
3 A3; 3 14.65 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (30995742..31052740)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (30894693..30951662)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene polyhomeotic 3 Neighboring gene predicted gene 2979 Neighboring gene microRNA 7008 Neighboring gene predicted gene, 33641 Neighboring gene predicted gene, 33694 Neighboring gene SKI-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4165

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Golgi vesicle budding ISO
Inferred from Sequence Orthology
more info
 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
establishment of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C iota type
Names
aPKC-lambda/iota
atypical protein kinase C-lambda/iota
nPKC-iota
protein kinase C, lambda
NP_032883.2
XP_006535474.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008857.3NP_032883.2  protein kinase C iota type

    See identical proteins and their annotated locations for NP_032883.2

    Status: VALIDATED

    Source sequence(s)
    AK009442, AK220517
    Consensus CDS
    CCDS17289.2
    UniProtKB/Swiss-Prot
    Q62074
    UniProtKB/TrEMBL
    Q5DTK3
    Related
    ENSMUSP00000103884.2, OTTMUSP00000043573, ENSMUST00000108249.8, OTTMUST00000081432
    Conserved Domains (3) summary
    cd06404
    Location:26108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:232595
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    pfam00130
    Location:141193
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    30995742..31052740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535411.3XP_006535474.2  protein kinase C iota type isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:223491
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05618
    Location:202565
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    pfam00130
    Location:111163
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:2679
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
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