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Prkci protein kinase C, iota [ Mus musculus (house mouse) ]

Gene ID: 18759, updated on 6-Jun-2024

Summary

Official Symbol
Prkciprovided by MGI
Official Full Name
protein kinase C, iotaprovided by MGI
Primary source
MGI:MGI:99260
See related
Ensembl:ENSMUSG00000037643 AllianceGenome:MGI:99260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkci; Pkcl; Prkcl; PKClambda; mKIAA4165; aPKClambda; 2310021H13Rik
Summary
Enables protein kinase C activity. Involved in several processes, including cellular response to insulin stimulus; positive regulation of glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organization; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 26.7), placenta adult (RPKM 19.4) and 28 other tissues See more
Orthologs
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Genomic context

See Prkci in Genome Data Viewer
Location:
3 A3; 3 14.65 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (31049893..31106889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30995742..31052740)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene polyhomeotic 3 Neighboring gene STARR-positive B cell enhancer ABC_E4537 Neighboring gene predicted gene 2979 Neighboring gene STARR-positive B cell enhancer ABC_E4538 Neighboring gene STARR-seq mESC enhancer starr_07307 Neighboring gene STARR-seq mESC enhancer starr_07308 Neighboring gene STARR-seq mESC enhancer starr_07310 Neighboring gene microRNA 7008 Neighboring gene STARR-seq mESC enhancer starr_07312 Neighboring gene predicted gene, 33641 Neighboring gene predicted gene, 33694 Neighboring gene STARR-positive B cell enhancer ABC_E9544 Neighboring gene STARR-positive B cell enhancer ABC_E2067 Neighboring gene STARR-seq mESC enhancer starr_07316 Neighboring gene SKI-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 
  • Targeted (10)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4165

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi vesicle budding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of PAR polarity complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C iota type
Names
aPKC-lambda/iota
atypical protein kinase C-lambda/iota
nPKC-iota
protein kinase C, lambda
NP_032883.2
XP_006535474.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428640.1NP_001415569.1  protein kinase C iota type isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC117590
    UniProtKB/TrEMBL
    Q3TJJ5
  2. NM_008857.4NP_032883.2  protein kinase C iota type isoform 1

    See identical proteins and their annotated locations for NP_032883.2

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC117590
    Consensus CDS
    CCDS17289.2
    UniProtKB/Swiss-Prot
    Q62074
    UniProtKB/TrEMBL
    Q3TJJ5
    Related
    ENSMUSP00000103884.3, ENSMUST00000108249.9
    Conserved Domains (3) summary
    cd06404
    Location:26108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:232595
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    pfam00130
    Location:141193
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    31049893..31106889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535411.5XP_006535474.2  protein kinase C iota type isoform X1

    Conserved Domains (3) summary
    cd05618
    Location:202565
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    pfam00130
    Location:111161
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:2679
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...