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Prkcd protein kinase C, delta [ Mus musculus (house mouse) ]

Gene ID: 18753, updated on 9-Mar-2023

Summary

Official Symbol
Prkcdprovided by MGI
Official Full Name
protein kinase C, deltaprovided by MGI
Primary source
MGI:MGI:97598
See related
Ensembl:ENSMUSG00000021948 AllianceGenome:MGI:97598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcd; PKC[d]; PKCdelta; D14Ertd420e
Summary
Enables insulin receptor substrate binding activity and protein kinase C activity. Involved in several processes, including negative regulation of cellular component organization; negative regulation of insulin receptor signaling pathway; and negative regulation of platelet aggregation. Acts upstream of or within B cell proliferation; immunoglobulin mediated immune response; and positive regulation of apoptotic signaling pathway. Located in several cellular components, including cell-cell junction; cytoplasm; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; fatty liver disease; and hypertension. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 37.2), adrenal adult (RPKM 35.9) and 25 other tissues See more
Orthologs
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Genomic context

See Prkcd in Genome Data Viewer
Location:
14 B; 14 18.82 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30317310..30348637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30595353..30626414, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1D subunit Neighboring gene predicted gene, 35566 Neighboring gene decapping mRNA 1A Neighboring gene microRNA 3076 Neighboring gene transketolase Neighboring gene predicted gene, 52147 Neighboring gene predicted gene, 53839 Neighboring gene RFT1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables TIR domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-independent protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in D-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydroperoxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucosylceramide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sphingomyelin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in termination of signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endolysosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C delta type
Names
nPKC-delta
protein kinase C, delta IV
protein kinase C, delta V
protein kinase C[d]
tyrosine-protein kinase PRKCD
NP_001297611.1
NP_035233.1
XP_006518758.1
XP_006518760.1
XP_006518761.1
XP_017171407.1
XP_030103546.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310682.1NP_001297611.1  protein kinase C delta type isoform 1

    See identical proteins and their annotated locations for NP_001297611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA616214, AC154646, AI385711, AK168768, AW122017, BY750197, CF170573
    Consensus CDS
    CCDS79285.1
    UniProtKB/TrEMBL
    Q3TGE4
    Related
    ENSMUSP00000022521.7, ENSMUST00000022521.13
    Conserved Domains (2) summary
    pfam00130
    Location:231281
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:377692
    PKc_like; Protein Kinases, catalytic domain
  2. NM_011103.3NP_035233.1  protein kinase C delta type isoform 2

    See identical proteins and their annotated locations for NP_035233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AF251036, AK171476, AW122017
    Consensus CDS
    CCDS26895.1
    UniProtKB/Swiss-Prot
    P28867, Q9Z333
    UniProtKB/TrEMBL
    Q53YN4
    Related
    ENSMUSP00000107829.4, ENSMUST00000112210.11
    Conserved Domains (2) summary
    pfam00130
    Location:231281
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:351666
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30317310..30348637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518695.2XP_006518758.1  protein kinase C delta type isoform X1

    See identical proteins and their annotated locations for XP_006518758.1

    UniProtKB/Swiss-Prot
    P28867
    Related
    ENSMUSP00000107830.3, ENSMUST00000112211.9
    Conserved Domains (2) summary
    pfam00130
    Location:231281
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:377692
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017315918.3XP_017171407.1  protein kinase C delta type isoform X1

    UniProtKB/Swiss-Prot
    P28867
    Conserved Domains (2) summary
    pfam00130
    Location:231281
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:377692
    PKc_like; Protein Kinases, catalytic domain
  3. XM_030247686.1XP_030103546.1  protein kinase C delta type isoform X3

    UniProtKB/Swiss-Prot
    Q9Z333
    UniProtKB/TrEMBL
    Q53YN4
    Conserved Domains (2) summary
    pfam00130
    Location:231281
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:351666
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006518698.5XP_006518761.1  protein kinase C delta type isoform X4

    Related
    ENSMUSP00000107822.2, ENSMUST00000112203.2
    Conserved Domains (2) summary
    pfam00130
    Location:231281
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:351624
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006518697.4XP_006518760.1  protein kinase C delta type isoform X2

    Related
    ENSMUSP00000107821.2, ENSMUST00000112202.8
    Conserved Domains (2) summary
    pfam00130
    Location:231281
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:377650
    PKc_like; Protein Kinases, catalytic domain