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PRKCD protein kinase C delta [ Homo sapiens (human) ]

Gene ID: 5580, updated on 4-Oct-2020

Summary

Official Symbol
PRKCDprovided by HGNC
Official Full Name
protein kinase C deltaprovided by HGNC
Primary source
HGNC:HGNC:9399
See related
Ensembl:ENSG00000163932 MIM:176977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAY1; PKCD; ALPS3; CVID9; nPKC-delta
Summary
The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in adrenal (RPKM 23.1), bone marrow (RPKM 21.7) and 25 other tissues See more
Orthologs

Genomic context

See PRKCD in Genome Data Viewer
Location:
3p21.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (53161209..53192717)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53195223..53226733)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 3 Neighboring gene RFT1 homolog Neighboring gene Sharpr-MPRA regulatory region 8375 Neighboring gene transketolase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Autoimmune lymphoproliferative syndrome, type III
MedGen: C3809928 OMIM: 615559 GeneReviews: Not available
Compare labs
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
Tat tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
tat Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3 PubMed
tat HIV-1 Tat-mediated stimulation of IL-10 production through the activation of PKC delta, but not TNF-alpha, requires p38 MAP kinase in human macrophages PubMed
tat HIV-1 Tat-mediated stimulation of IL-10 and TNF-alpha production through the activation of PKC delta requires ERK1/2 MAP kinase and NF-kappaB transcription factor in human macrophages PubMed
tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC49908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
calcium-independent protein kinase C activity TAS
Traceable Author Statement
more info
PubMed 
enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor substrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to angiotensin IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydroperoxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
histone phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein binding TAS
Traceable Author Statement
more info
PubMed 
neutrophil activation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endodeoxyribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucosylceramide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phospholipid scramblase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sphingomyelin catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
termination of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein kinase C delta type
Names
protein kinase C delta VIII
tyrosine-protein kinase PRKCD
NP_001303256.1
NP_001341605.1
NP_001341607.1
NP_001341608.1
NP_001341609.1
NP_006245.2
NP_997704.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033864.2 RefSeqGene

    Range
    10201..41709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1327

mRNA and Protein(s)

  1. NM_001316327.2NP_001303256.1  protein kinase C delta type isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
    Source sequence(s)
    AC097015, AK294272, AK313216, AW293041, BC043350
    Consensus CDS
    CCDS2870.1
    UniProtKB/Swiss-Prot
    Q05655
    UniProtKB/TrEMBL
    A0A024R328, B4DFV1
    Conserved Domains (2) summary
    cd05620
    Location:353668
    STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
    pfam00130
    Location:231283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. NM_001354676.2NP_001341605.1  protein kinase C delta type isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (a).
    Source sequence(s)
    AC097015
    Conserved Domains (2) summary
    cd05620
    Location:372687
    STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
    pfam00130
    Location:250302
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  3. NM_001354678.2NP_001341607.1  protein kinase C delta type isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC097015
    Conserved Domains (2) summary
    cd05620
    Location:369684
    STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
    pfam00130
    Location:247299
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  4. NM_001354679.2NP_001341608.1  protein kinase C delta type isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
    Source sequence(s)
    AC097015
    Consensus CDS
    CCDS2870.1
    Related
    ENSP00000498623.1, ENST00000650739.1
    Conserved Domains (2) summary
    cd05620
    Location:353668
    STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
    pfam00130
    Location:231283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  5. NM_001354680.2NP_001341609.1  protein kinase C delta type isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
    Source sequence(s)
    AC097015
    Consensus CDS
    CCDS2870.1
    Related
    ENSP00000498400.1, ENST00000652449.1
    Conserved Domains (2) summary
    cd05620
    Location:353668
    STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
    pfam00130
    Location:231283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  6. NM_006254.4NP_006245.2  protein kinase C delta type isoform c

    See identical proteins and their annotated locations for NP_006245.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
    Source sequence(s)
    AW293041, BC043350, BE048101, CD369320, L07861
    Consensus CDS
    CCDS2870.1
    UniProtKB/Swiss-Prot
    Q05655
    UniProtKB/TrEMBL
    A0A024R328
    Related
    ENSP00000331602.3, ENST00000330452.8
    Conserved Domains (2) summary
    cd05620
    Location:353668
    STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
    pfam00130
    Location:231283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  7. NM_212539.2NP_997704.1  protein kinase C delta type isoform c

    See identical proteins and their annotated locations for NP_997704.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
    Source sequence(s)
    AW293041, BC043350, BE048101, CD369320, L07861
    Consensus CDS
    CCDS2870.1
    UniProtKB/Swiss-Prot
    Q05655
    UniProtKB/TrEMBL
    A0A024R328
    Related
    ENSP00000378217.2, ENST00000394729.6
    Conserved Domains (2) summary
    cd05620
    Location:353668
    STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
    pfam00130
    Location:231283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    53161209..53192717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002959550.1 RNA Sequence

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