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Prkacb protein kinase, cAMP dependent, catalytic, beta [ Mus musculus (house mouse) ]

Gene ID: 18749, updated on 5-Mar-2024

Summary

Official Symbol
Prkacbprovided by MGI
Official Full Name
protein kinase, cAMP dependent, catalytic, betaprovided by MGI
Primary source
MGI:MGI:97594
See related
Ensembl:ENSMUSG00000005034 AllianceGenome:MGI:97594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CbPKA; Pkacb; PKA C-beta
Summary
Enables ATP binding activity; cAMP-dependent protein kinase activity; and magnesium ion binding activity. Involved in protein phosphorylation. Acts upstream of or within negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; and regulation of protein processing. Located in ciliary base. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 53.9), CNS E18 (RPKM 48.1) and 25 other tissues See more
Orthologs
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Genomic context

See Prkacb in Genome Data Viewer
Location:
3 H2; 3 72.28 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146435334..146518691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146729579..146812946, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:146349571-146349754 Neighboring gene predicted gene, 36521 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09230 Neighboring gene STARR-positive B cell enhancer ABC_E4605 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:146444299-146444452 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 1 pseudogene Neighboring gene ribosomal protein L11 pseudogene Neighboring gene tubulin tyrosine ligase-like family, member 7 Neighboring gene STARR-seq mESC enhancer starr_09232 Neighboring gene STARR-positive B cell enhancer ABC_E6145

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of cAMP-dependent protein kinase complex TAS
Traceable Author Statement
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase catalytic subunit beta
Names
Cbeta2 PKA
cAMP-dependent protein kinase C beta
NP_001157670.1
NP_001157671.1
NP_001157672.1
NP_001397387.1
NP_001397388.1
NP_001397389.1
NP_035230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164198.2NP_001157670.1  cAMP-dependent protein kinase catalytic subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001157670.1

    Status: VALIDATED

    Source sequence(s)
    AC114618
    Consensus CDS
    CCDS51090.1
    UniProtKB/Swiss-Prot
    P68181
    Related
    ENSMUSP00000101743.2, ENSMUST00000106137.8
    Conserved Domains (1) summary
    cd14209
    Location:29318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  2. NM_001164199.2NP_001157671.1  cAMP-dependent protein kinase catalytic subunit beta isoform 3

    See identical proteins and their annotated locations for NP_001157671.1

    Status: VALIDATED

    Source sequence(s)
    AC114618
    Consensus CDS
    CCDS51091.1
    UniProtKB/Swiss-Prot
    P68181
    Related
    ENSMUSP00000101744.2, ENSMUST00000106138.8
    Conserved Domains (1) summary
    cd14209
    Location:30319
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  3. NM_001164200.2NP_001157672.1  cAMP-dependent protein kinase catalytic subunit beta isoform 4

    See identical proteins and their annotated locations for NP_001157672.1

    Status: VALIDATED

    Source sequence(s)
    AC114618
    Consensus CDS
    CCDS51092.1
    UniProtKB/Swiss-Prot
    P68181
    Related
    ENSMUSP00000005164.8, ENSMUST00000005164.12
    Conserved Domains (2) summary
    PTZ00263
    Location:79398
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:89378
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  4. NM_001410458.1NP_001397387.1  cAMP-dependent protein kinase catalytic subunit beta isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC114618
  5. NM_001410459.1NP_001397388.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC114618, AC115889
  6. NM_001410460.1NP_001397389.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC114618, AC115889
  7. NM_011100.5NP_035230.1  cAMP-dependent protein kinase catalytic subunit beta isoform 1

    See identical proteins and their annotated locations for NP_035230.1

    Status: VALIDATED

    Source sequence(s)
    AC114618, AC115889
    Consensus CDS
    CCDS17906.1
    UniProtKB/Swiss-Prot
    P68181, Q3TQH5, Q3UDD0, Q3UTH5
    Related
    ENSMUSP00000099573.4, ENSMUST00000102515.10
    Conserved Domains (1) summary
    cd14209
    Location:42331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146435334..146518691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)