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PRKACB protein kinase cAMP-activated catalytic subunit beta [ Homo sapiens (human) ]

Gene ID: 5567, updated on 9-Jan-2021

Summary

Official Symbol
PRKACBprovided by HGNC
Official Full Name
protein kinase cAMP-activated catalytic subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9381
See related
Ensembl:ENSG00000142875 MIM:176892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAFD2; PKACB; PKA C-beta
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]
Expression
Broad expression in brain (RPKM 61.5), colon (RPKM 21.8) and 22 other tissues See more
Orthologs
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Genomic context

See PRKACB in Genome Data Viewer
Location:
1p31.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (84078079..84238498)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (84543745..84704181)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1725 Neighboring gene uncharacterized LOC101927560 Neighboring gene uncharacterized LOC107985041 Neighboring gene tubulin tyrosine ligase like 7 Neighboring gene uncharacterized LOC107985046 Neighboring gene TXN2 pseudogene 1 Neighboring gene uncharacterized LOC112268230 Neighboring gene NEDD8 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
CARDIOACROFACIAL DYSPLASIA 2
MedGen: CN293614 OMIM: 619143 GeneReviews: Not available
not available
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed
env The exposure of CD4+ T cells to HIV gp120 results in a long-lasting hyporesponsiveness to antigen stimulation through protein kinase A-mediated signaling PubMed
env Treatment of normal human fibroblasts with HIV-1 gp120 protein results in a significant decrease in the levels of 8-azido-[32P]cAMP binding to RI and RII domains of protein kinase A (PKA) and in PKA activity PubMed
Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
Tat tat The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway PubMed
tat HIV-1 Tat-peptide(48-60) inhibits protein kinase C alpha and protein kinase A in a concentration-dependent manner PubMed
tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
capsid gag cAMP-dependent protein kinase is incorporated into HIV-1 virions, interacts with and phosphorylates the HIV-1 Capsid protein, and regulates HIV-1 infectivity PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9320, MGC41879, DKFZp586F2323, DKFZp781I2452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase A activity TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
high-density lipoprotein particle assembly TAS
Traceable Author Statement
more info
 
negative regulation of meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning IEA
Inferred from Electronic Annotation
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
renal water homeostasis TAS
Traceable Author Statement
more info
 
response to clozapine IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cAMP-dependent protein kinase complex TAS
Traceable Author Statement
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary base TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase catalytic subunit beta
Names
protein kinase A catalytic subunit beta
protein kinase, cAMP-dependent, beta catalytic subunit
protein kinase, cAMP-dependent, catalytic, beta
NP_001229786.1
NP_001229787.1
NP_001229788.1
NP_001229789.1
NP_001229790.1
NP_001229791.1
NP_001287844.1
NP_001287845.1
NP_001287846.1
NP_001362489.1
NP_001362490.1
NP_001362491.1
NP_001362492.1
NP_001362493.1
NP_001362494.1
NP_001362498.1
NP_001362500.1
NP_001362501.1
NP_001362502.1
NP_001362503.1
NP_001362504.1
NP_001362505.1
NP_001362506.1
NP_001362507.1
NP_001362508.1
NP_001362509.1
NP_001362510.1
NP_002722.1
NP_891993.1
NP_997461.1
XP_005271077.1
XP_016857200.1
XP_016857205.1
XP_016857206.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029728.1 RefSeqGene

    Range
    4914..165437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242857.3NP_001229786.1  cAMP-dependent protein kinase catalytic subunit beta isoform 4

    See identical proteins and their annotated locations for NP_001229786.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' exon structure, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK296482, AL450063, BX641026, DC322547
    Consensus CDS
    CCDS55609.1
    UniProtKB/Swiss-Prot
    P22694
    Related
    ENSP00000401252.2, ENST00000446538.5
    Conserved Domains (1) summary
    cd14209
    Location:49338
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  2. NM_001242858.3NP_001229787.1  cAMP-dependent protein kinase catalytic subunit beta isoform 5

    See identical proteins and their annotated locations for NP_001229787.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' exon structure, compared to variant 1. The encoded isoform (5, also known as Cbeta3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK304375, AL450063, BX641026, DC322547
    Consensus CDS
    CCDS72813.1
    UniProtKB/Swiss-Prot
    P22694
    Related
    ENSP00000481980.1, ENST00000610703.4
    Conserved Domains (1) summary
    cd14209
    Location:30319
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  3. NM_001242859.3NP_001229788.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

    See identical proteins and their annotated locations for NP_001229788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' exon structure, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL450063, BX641026
    Consensus CDS
    CCDS55610.1
    UniProtKB/Swiss-Prot
    P22694
    Related
    ENSP00000359716.3, ENST00000370682.7
    Conserved Domains (1) summary
    cd14209
    Location:46335
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  4. NM_001242860.3NP_001229789.1  cAMP-dependent protein kinase catalytic subunit beta isoform 7

    See identical proteins and their annotated locations for NP_001229789.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' exon structure, compared to variant 1. The encoded isoform (7, also known as Cbeta4abc) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB209189, AL450063, BX641026, DA188681
    Consensus CDS
    CCDS72815.1
    UniProtKB/Swiss-Prot
    P22694
    Related
    ENSP00000479722.1, ENST00000614872.4
    Conserved Domains (1) summary
    cd14209
    Location:48337
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  5. NM_001242861.3NP_001229790.1  cAMP-dependent protein kinase catalytic subunit beta isoform 8

    See identical proteins and their annotated locations for NP_001229790.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' exon structure, compared to variant 1. The encoded isoform (8, also known as Cbeta4ab) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK091420, AL450063, BX641026, DA188681
    Consensus CDS
    CCDS55611.1
    UniProtKB/Swiss-Prot
    P22694
    Related
    ENSP00000378315.2, ENST00000394839.6
    Conserved Domains (1) summary
    cd14209
    Location:45301
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  6. NM_001242862.3NP_001229791.1  cAMP-dependent protein kinase catalytic subunit beta isoform 9

    See identical proteins and their annotated locations for NP_001229791.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' exon structure, compared to variant 1. The encoded isoform (9) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK316115, AL450063, BX641026, DA228647
    Consensus CDS
    CCDS72816.1
    UniProtKB/Swiss-Prot
    P22694
    UniProtKB/TrEMBL
    A0A087WVC4, B7ZA00
    Related
    ENSP00000479339.1, ENST00000610457.1
    Conserved Domains (1) summary
    cd14209
    Location:29318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  7. NM_001300915.2NP_001287844.1  cAMP-dependent protein kinase catalytic subunit beta isoform 10

    See identical proteins and their annotated locations for NP_001287844.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (10) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BX369882, BX647515, DA188681
    Consensus CDS
    CCDS72814.1
    UniProtKB/Swiss-Prot
    P22694
    UniProtKB/TrEMBL
    B1APG3
    Related
    ENSP00000359714.1, ENST00000370680.5
    Conserved Domains (1) summary
    cl21453
    Location:48264
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001300916.2NP_001287845.1  cAMP-dependent protein kinase catalytic subunit beta isoform 11

    See identical proteins and their annotated locations for NP_001287845.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 3' exon structure, compared to variant 1. The encoded isoform (11) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BM905428, BX369882, DC418574
    UniProtKB/Swiss-Prot
    P22694
    Conserved Domains (1) summary
    cl21453
    Location:89302
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001300917.2NP_001287846.1  cAMP-dependent protein kinase catalytic subunit beta isoform 12

    See identical proteins and their annotated locations for NP_001287846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (12) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BI598037, BX369882, DC322547
    Consensus CDS
    CCDS72812.1
    UniProtKB/Swiss-Prot
    P22694
    UniProtKB/TrEMBL
    B1APF9
    Related
    ENSP00000359718.1, ENST00000370684.5
    Conserved Domains (1) summary
    cl21453
    Location:30243
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001375560.1NP_001362489.1  cAMP-dependent protein kinase catalytic subunit beta isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cd14209
    Location:45334
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  11. NM_001375561.1NP_001362490.1  cAMP-dependent protein kinase catalytic subunit beta isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cd14209
    Location:40329
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  12. NM_001375562.1NP_001362491.1  cAMP-dependent protein kinase catalytic subunit beta isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cd14209
    Location:41330
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  13. NM_001375563.1NP_001362492.1  cAMP-dependent protein kinase catalytic subunit beta isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cd14209
    Location:38327
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  14. NM_001375564.1NP_001362493.1  cAMP-dependent protein kinase catalytic subunit beta isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cd14209
    Location:37326
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  15. NM_001375565.1NP_001362494.1  cAMP-dependent protein kinase catalytic subunit beta isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cd14209
    Location:29318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  16. NM_001375569.1NP_001362498.1  cAMP-dependent protein kinase catalytic subunit beta isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:49262
    PKc_like; Protein Kinases, catalytic domain
  17. NM_001375571.1NP_001362500.1  cAMP-dependent protein kinase catalytic subunit beta isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:48261
    PKc_like; Protein Kinases, catalytic domain
  18. NM_001375572.1NP_001362501.1  cAMP-dependent protein kinase catalytic subunit beta isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:46262
    PKc_like; Protein Kinases, catalytic domain
  19. NM_001375573.1NP_001362502.1  cAMP-dependent protein kinase catalytic subunit beta isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:45261
    PKc_like; Protein Kinases, catalytic domain
  20. NM_001375574.1NP_001362503.1  cAMP-dependent protein kinase catalytic subunit beta isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:40256
    PKc_like; Protein Kinases, catalytic domain
  21. NM_001375575.1NP_001362504.1  cAMP-dependent protein kinase catalytic subunit beta isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:45258
    PKc_like; Protein Kinases, catalytic domain
  22. NM_001375576.1NP_001362505.1  cAMP-dependent protein kinase catalytic subunit beta isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL359504, AL450063
    Conserved Domains (1) summary
    cl21453
    Location:42258
    PKc_like; Protein Kinases, catalytic domain
  23. NM_001375577.1NP_001362506.1  cAMP-dependent protein kinase catalytic subunit beta isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:40253
    PKc_like; Protein Kinases, catalytic domain
  24. NM_001375578.1NP_001362507.1  cAMP-dependent protein kinase catalytic subunit beta isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:30246
    PKc_like; Protein Kinases, catalytic domain
  25. NM_001375579.1NP_001362508.1  cAMP-dependent protein kinase catalytic subunit beta isforom 29

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:29245
    PKc_like; Protein Kinases, catalytic domain
  26. NM_001375580.1NP_001362509.1  cAMP-dependent protein kinase catalytic subunit beta isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Related
    ENSP00000399326.1, ENST00000417530.5
    Conserved Domains (1) summary
    cl21453
    Location:29242
    PKc_like; Protein Kinases, catalytic domain
  27. NM_001375581.1NP_001362510.1  cAMP-dependent protein kinase catalytic subunit beta isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:49265
    PKc_like; Protein Kinases, catalytic domain
  28. NM_002731.4NP_002722.1  cAMP-dependent protein kinase catalytic subunit beta isoform 2

    See identical proteins and their annotated locations for NP_002722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' exon structure, compared to variant 1. The encoded isoform (2, also known as Cbeta1) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC035058, BX537705, BX641026, HY160843, M34181
    Consensus CDS
    CCDS691.1
    UniProtKB/Swiss-Prot
    P22694
    UniProtKB/TrEMBL
    B2RB89
    Related
    ENSP00000359723.2, ENST00000370689.6
    Conserved Domains (1) summary
    cd14209
    Location:42331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  29. NM_182948.4NP_891993.1  cAMP-dependent protein kinase catalytic subunit beta isoform 1

    See identical proteins and their annotated locations for NP_891993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Cbeta2).
    Source sequence(s)
    BC035058, BX485407, BX537705, BX641026, M34181
    Consensus CDS
    CCDS693.1
    UniProtKB/Swiss-Prot
    P22694
    Related
    ENSP00000359719.3, ENST00000370685.7
    Conserved Domains (1) summary
    cd14209
    Location:89378
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
  30. NM_207578.3NP_997461.1  cAMP-dependent protein kinase catalytic subunit beta isoform 3

    See identical proteins and their annotated locations for NP_997461.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (3) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BX369882, HY160843
    Consensus CDS
    CCDS692.1
    UniProtKB/Swiss-Prot
    P22694
    Related
    ENSP00000359722.3, ENST00000370688.7
    Conserved Domains (1) summary
    cl21453
    Location:42255
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    84078079..84238498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271020.2XP_005271077.1  cAMP-dependent protein kinase catalytic subunit beta isoform X7

    See identical proteins and their annotated locations for XP_005271077.1

    Conserved Domains (1) summary
    cl21453
    Location:89305
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017001716.1XP_016857205.1  cAMP-dependent protein kinase catalytic subunit beta isoform X18

    Related
    ENSP00000392275.1, ENST00000432111.5
  3. XM_017001711.1XP_016857200.1  cAMP-dependent protein kinase catalytic subunit beta isoform X13

    Conserved Domains (1) summary
    cl21453
    Location:46259
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017001717.1XP_016857206.1  cAMP-dependent protein kinase catalytic subunit beta isoform X19

    Related
    ENSP00000397175.1, ENST00000413538.5
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