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cyp-14A2 CYtochrome P450 family [ Caenorhabditis elegans ]

Gene ID: 187184, updated on 25-Apr-2024

Summary

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Gene symbol
cyp-14A2
Gene description
CYtochrome P450 family
Primary source
WormBase:WBGene00010706
Locus tag
CELE_K09A11.3
See related
AllianceGenome:WB:WBGene00010706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in intestine. Human ortholog(s) of this gene implicated in asthma; autoimmune hepatitis; hereditary spastic paraplegia 56; leukemia (multiple); and rhinitis. Orthologous to several human genes including CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (13267562..13269686, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans. Kulas J, et al. Arch Biochem Biophys, 2008 Apr 1. PMID 18282462
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CYtochrome P450 family
NP_510204.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13267562..13269686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077803.4 → NP_510204.1  CYtochrome P450 family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27505
    Conserved Domains (1) summary
    pfam00067
    Location:27 → 484
    p450; Cytochrome P450
Nucleotide Protein
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