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Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [ Mus musculus (house mouse) ]

Gene ID: 18707, updated on 11-Apr-2024

Summary

Official Symbol
Pik3cdprovided by MGI
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaprovided by MGI
Primary source
MGI:MGI:1098211
See related
Ensembl:ENSMUSG00000039936 AllianceGenome:MGI:1098211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p110delta; 2410099E07Rik; 2610208K16Rik
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in positive regulation of angiogenesis and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including B cell activation; B cell homeostasis; and defense response to fungus. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in early embryo; hemolymphoid system; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 42.3), thymus adult (RPKM 28.3) and 18 other tissues See more
Orthologs
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Genomic context

See Pik3cd in Genome Data Viewer
Location:
4 E2; 4 80.15 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149733625..149787023, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149649168..149702566, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene catenin beta interacting protein 1 Neighboring gene predicted gene 13066 Neighboring gene calsyntenin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149032165-149032348 Neighboring gene microRNA 7023 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149063846-149064146 Neighboring gene STARR-positive B cell enhancer ABC_E9249 Neighboring gene STARR-positive B cell enhancer ABC_E2730 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149084694-149084994 Neighboring gene transmembrane protein 201 Neighboring gene solute carrier family 25, member 33 Neighboring gene STARR-seq mESC enhancer starr_12124

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial tube formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphatidylinositol 3-kinase complex, class IA ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Names
PI3-kinase subunit delta
PI3K-delta
PI3Kdelta
catalytic phosphatidylinositol 3-kinase delta
p100 delta
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic subunit delta
phosphatidylinositol 3-kinase p110 delta
phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
phosphoinositide 3 kinase P110delta
ptdIns-3-kinase subunit delta
ptdIns-3-kinase subunit p110-delta
NP_001025008.2
NP_001157521.1
NP_001157522.1
NP_001157523.1
NP_001157524.1
NP_032866.2
XP_006538704.1
XP_006538705.1
XP_006538706.1
XP_006538707.1
XP_006538708.1
XP_006538709.1
XP_006538710.1
XP_006538711.1
XP_006538712.1
XP_006538713.1
XP_006538714.1
XP_006538715.1
XP_006538716.1
XP_017175526.1
XP_017175527.1
XP_030109173.1
XP_030109174.1
XP_030109175.1
XP_036019722.1
XP_036019723.1
XP_036019724.1
XP_036019725.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029837.2NP_001025008.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b

    See identical proteins and their annotated locations for NP_001025008.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (b) includes an additional 3-aa internal segment, compared to isoform c. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK040867, AK149935, AK153304, AW124359, CF164288
    Consensus CDS
    CCDS51384.1
    UniProtKB/TrEMBL
    Q3T9Y0, Q8BS14
    Related
    ENSMUSP00000136045.2, ENSMUST00000177654.8
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504687
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6791045
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  2. NM_001164049.1NP_001157521.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b

    See identical proteins and their annotated locations for NP_001157521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (b) includes an additional 3-aa internal segment, compared to isoform c. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AL607078, AL626808
    Consensus CDS
    CCDS51384.1
    UniProtKB/TrEMBL
    Q3T9Y0, Q8BS14
    Related
    ENSMUSP00000101315.3, ENSMUST00000105690.9
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504687
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6791045
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  3. NM_001164050.1NP_001157522.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform d

    See identical proteins and their annotated locations for NP_001157522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (d) includes an additional 1-aa internal segment, compared to isoform c.
    Source sequence(s)
    AL607078, AL626808
    Consensus CDS
    CCDS51383.1
    UniProtKB/TrEMBL
    B0QZL5, Q546P7, Q8BS14, Q8CI98
    Related
    ENSMUSP00000036434.8, ENSMUST00000038859.14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761043
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  4. NM_001164051.1NP_001157523.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform e

    See identical proteins and their annotated locations for NP_001157523.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR, and uses two alternate in-frame splice sites in the central coding region, compared to variant 4. The resulting isoform (e) lacks a 1-aa internal segment and includes an additional 3-aa internal segments, compared to isoform c.
    Source sequence(s)
    AL607078
    Consensus CDS
    CCDS51381.1
    UniProtKB/TrEMBL
    Q3TBW3, Q8BS14
    Related
    ENSMUSP00000112863.2, ENSMUST00000118704.8
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505686
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6781044
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  5. NM_001164052.1NP_001157524.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a

    See identical proteins and their annotated locations for NP_001157524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the central coding region, compared to variant 4. The promoter and 5' UTR for this variant has not been determined. The resulting isoform (a) lacks a 1-aa internal segment, compared to isoform a.
    Source sequence(s)
    AL607078
    Consensus CDS
    CCDS51380.1
    UniProtKB/Swiss-Prot
    O35904, Q8CJ28
    UniProtKB/TrEMBL
    Q546P7
    Related
    ENSMUSP00000101314.2, ENSMUST00000105689.8
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505683
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6751041
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  6. NM_008840.3NP_032866.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform c

    See identical proteins and their annotated locations for NP_032866.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes isoform c.
    Source sequence(s)
    AK040867, AK149935, AK153304, AL626808, AW124359
    Consensus CDS
    CCDS51382.1
    UniProtKB/TrEMBL
    B0QZL5, Q3UDT3, Q546P7, Q8BS14
    Related
    ENSMUSP00000101313.4, ENSMUST00000105688.10
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149733625..149787023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538646.1XP_006538709.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006538709.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  2. XM_006538643.2XP_006538706.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006538706.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  3. XM_017320037.2XP_017175526.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  4. XM_006538642.5XP_006538705.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006538705.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  5. XM_006538648.5XP_006538711.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

    See identical proteins and their annotated locations for XP_006538711.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505712
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7041071
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  6. XM_006538641.5XP_006538704.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006538704.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  7. XM_036163829.1XP_036019722.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  8. XM_030253313.2XP_030109173.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8

    UniProtKB/TrEMBL
    Q546P7
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505683
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6751042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  9. XM_017320038.3XP_017175527.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504687
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6791046
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  10. XM_006538650.5XP_006538713.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

    See identical proteins and their annotated locations for XP_006538713.1

    UniProtKB/TrEMBL
    B0QZL5, Q546P7, Q8BS14, Q8CI98
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761043
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  11. XM_006538644.5XP_006538707.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006538707.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  12. XM_006538645.1XP_006538708.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006538708.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051072
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  13. XM_006538653.2XP_006538716.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X10

    See identical proteins and their annotated locations for XP_006538716.1

    Conserved Domains (3) summary
    cd08693
    Location:79219
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:242451
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:443810
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
  14. XM_036163832.1XP_036019725.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X13

    Conserved Domains (3) summary
    cd08693
    Location:79219
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:243421
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:413780
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
  15. XM_030253314.2XP_030109174.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X11

    Conserved Domains (3) summary
    cd08693
    Location:79219
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:242422
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:414781
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
  16. XM_036163830.1XP_036019723.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

    UniProtKB/TrEMBL
    B0QZL5, Q3UDT3, Q546P7, Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  17. XM_006538647.5XP_006538710.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

    See identical proteins and their annotated locations for XP_006538710.1

    UniProtKB/TrEMBL
    Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504713
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7051071
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  18. XM_006538652.5XP_006538715.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X9

    See identical proteins and their annotated locations for XP_006538715.1

    UniProtKB/Swiss-Prot
    O35904, Q8CJ28
    UniProtKB/TrEMBL
    Q546P7
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505683
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6751041
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  19. XM_006538651.4XP_006538714.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

    See identical proteins and their annotated locations for XP_006538714.1

    UniProtKB/TrEMBL
    B0QZL5, Q3UDT3, Q546P7, Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  20. XM_006538649.4XP_006538712.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

    See identical proteins and their annotated locations for XP_006538712.1

    UniProtKB/TrEMBL
    Q3T9Y0, Q8BS14
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504687
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6791045
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:182281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  21. XM_030253315.2XP_030109175.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X14

    Conserved Domains (3) summary
    cd08693
    Location:79219
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:243421
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:413779
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
  22. XM_036163831.1XP_036019724.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X12

    Conserved Domains (3) summary
    cd08693
    Location:79219
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:242422
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:414780
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta