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PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [ Homo sapiens (human) ]

Gene ID: 5293, updated on 6-Sep-2021

Summary

Official Symbol
PIK3CDprovided by HGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaprovided by HGNC
Primary source
HGNC:HGNC:8977
See related
Ensembl:ENSG00000171608 MIM:602839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APDS; PI3K; IMD14; p110D; IMD14A; IMD14B; ROCHIS; P110DELTA
Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Expression
Broad expression in lymph node (RPKM 21.4), bone marrow (RPKM 20.0) and 22 other tissues See more
Orthologs
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Genomic context

See PIK3CD in Genome Data Viewer
Location:
1p36.22
Exon count:
30
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9629889..9729114)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9711789..9789172)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 67 enhancer Neighboring gene uncharacterized LOC105376712 Neighboring gene PIK3CD antisense RNA 1 Neighboring gene PIK3CD antisense RNA 2 Neighboring gene ribosomal protein L26 pseudogene 7 Neighboring gene calsyntenin 1 Neighboring gene mitotic spindle organizing protein 1 pseudogene 1 Neighboring gene uncharacterized LOC105376717 Neighboring gene catenin beta interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
Nef nef HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression PubMed
nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
Tat tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
tat Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells PubMed
tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed
tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed
Vpr vpr HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
vpr HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 1-phosphatidylinositol-3-kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol 3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylinositol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-3,4-bisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in B cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in B cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in adaptive immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in mast cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in mast cell degranulation TAS
Traceable Author Statement
more info
PubMed 
involved_in mast cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in natural killer cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in natural killer cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in natural killer cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in neutrophil extravasation TAS
Traceable Author Statement
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration by vascular endothelial growth factor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cytokine production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of epithelial tube formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in respiratory burst involved in defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Names
PI3-kinase p110 subunit delta
PI3Kdelta
phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 20
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20
phosphoinositide-3-kinase C
phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta
ptdIns-3-kinase subunit p110-delta
NP_001337163.1
NP_001337164.1
NP_005017.3
XP_006710750.1
XP_006710752.1
XP_016856965.1
XP_016856966.1
XP_016856967.1
XP_016856968.1
XP_016856969.1
XP_016856970.1
XP_016856971.1
XP_016856972.1
XP_024303429.1
XP_024303431.1
XP_024303432.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023434.1 RefSeqGene

    Range
    5001..82383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_191

mRNA and Protein(s)

  1. NM_001350234.2NP_001337163.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL691449, BC132919, BC150297, CA427830, DA318970, DB216922, U86453, W30913, Y10055
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505683
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6751041
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  2. NM_001350235.1NP_001337164.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 3

    Status: REVIEWED

    Source sequence(s)
    BC132919, BC150297, CA427830, DA318970, U86453, W30913, Y10055
    Conserved Domains (5) summary
    cd08693
    Location:285452
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:474655
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6471013
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175261
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  3. NM_005026.5NP_005017.3  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1

    See identical proteins and their annotated locations for NP_005017.3

    Status: REVIEWED

    Source sequence(s)
    AK314191, AL691449, BC030263, BC132919, BC150297, CA427830, U86453, W30913, Y10055
    Consensus CDS
    CCDS104.1
    UniProtKB/Swiss-Prot
    O00329
    Related
    ENSP00000366563.4, ENST00000377346.9
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:503684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    9629889..9729114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001477.1XP_016856966.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  2. XM_017001478.1XP_016856967.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  3. XM_017001480.1XP_016856969.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  4. XM_006710689.2XP_006710752.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

    See identical proteins and their annotated locations for XP_006710752.1

    UniProtKB/Swiss-Prot
    O00329
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:503684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  5. XM_024447664.1XP_024303432.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

    Conserved Domains (5) summary
    cd08693
    Location:285452
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:474655
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6471013
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175261
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  6. XM_024447661.1XP_024303429.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  7. XM_024447663.1XP_024303431.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505683
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6751041
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  8. XM_017001483.2XP_016856972.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

    Related
    ENSP00000486826.1, ENST00000628140.2
  9. XM_017001479.1XP_016856968.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Related
    ENSP00000354410.2, ENST00000361110.6
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  10. XM_017001481.1XP_016856970.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  11. XM_017001476.1XP_016856965.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  12. XM_006710687.2XP_006710750.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

    See identical proteins and their annotated locations for XP_006710750.1

    UniProtKB/Swiss-Prot
    O00329
    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:503684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:6761042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain
  13. XM_017001482.2XP_016856971.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:314481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:562743
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:7351101
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:175281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32107
    PI3K_p85B; PI3-kinase family, p85-binding domain

RNA

  1. XR_002956806.1 RNA Sequence

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