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Pex11a peroxisomal biogenesis factor 11 alpha [ Mus musculus (house mouse) ]

Gene ID: 18631, updated on 8-Feb-2024

Summary

Official Symbol
Pex11aprovided by MGI
Official Full Name
peroxisomal biogenesis factor 11 alphaprovided by MGI
Primary source
MGI:MGI:1338788
See related
Ensembl:ENSMUSG00000030545 AllianceGenome:MGI:1338788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEX11alpha
Summary
Predicted to enable protein homodimerization activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in peroxisome. Predicted to be integral component of peroxisomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in peroxisomal membrane. Orthologous to human PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.5), liver adult (RPKM 10.0) and 25 other tissues See more
Orthologs
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Genomic context

See Pex11a in Genome Data Viewer
Location:
7 45.12 cM; 7 D2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79385705..79392879, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79735957..79743131, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 7 Neighboring gene uncharacterized LOC118567517 Neighboring gene STARR-positive B cell enhancer mm9_chr7:86873152-86873453 Neighboring gene perilipin 1 Neighboring gene WD repeat domain 93 Neighboring gene predicted gene 44705

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome membrane biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peroxisome size ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal membrane protein 11A
Names
PEX11-alpha
peroxin-11A
peroxisomal biogenesis factor 11a
protein PEX11 homolog alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011068.2NP_035198.1  peroxisomal membrane protein 11A

    See identical proteins and their annotated locations for NP_035198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AK076776, AK149387
    Consensus CDS
    CCDS21386.1
    UniProtKB/Swiss-Prot
    Q8C5B8, Q9Z211
    UniProtKB/TrEMBL
    Q3UER4
    Related
    ENSMUSP00000032761.8, ENSMUST00000032761.8
    Conserved Domains (1) summary
    pfam05648
    Location:1237
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RNA

  1. NR_153403.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK076776, AK078954

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79385705..79392879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152777.1XP_036008670.1  peroxisomal membrane protein 11A isoform X1

    Conserved Domains (1) summary
    pfam05648
    Location:1212
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)