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PEX11A peroxisomal biogenesis factor 11 alpha [ Homo sapiens (human) ]

Gene ID: 8800, updated on 13-Mar-2020

Summary

Official Symbol
PEX11Aprovided by HGNC
Official Full Name
peroxisomal biogenesis factor 11 alphaprovided by HGNC
Primary source
HGNC:HGNC:8852
See related
Ensembl:ENSG00000166821 MIM:603866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMP28; hsPEX11p; PEX11-ALPHA
Summary
This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in fat (RPKM 14.4), prostate (RPKM 9.1) and 24 other tissues See more
Orthologs

Genomic context

See PEX11A in Genome Data Viewer
Location:
15q26.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (89681535..89690754, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90224762..90234015, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene TOPBP1 interacting checkpoint and replication regulator Neighboring gene kinesin family member 7 Neighboring gene perilipin 1 Neighboring gene ribosomal protein L36a pseudogene 43 Neighboring gene WD repeat domain 93 Neighboring gene RNA, U6 small nuclear 132, pseudogene Neighboring gene mesoderm posterior bHLH transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119947, MGC138534

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome fission IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome membrane biogenesis IEA
Inferred from Electronic Annotation
more info
 
peroxisome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of peroxisome size IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of peroxisome size IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisomal membrane TAS
Traceable Author Statement
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal membrane protein 11A
Names
28 kDa peroxisomal integral membrane protein
peroxin-11A
peroxisomal biogenesis factor 11A
protein PEX11 homolog alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271572.2NP_001258501.1  peroxisomal membrane protein 11A isoform 2

    See identical proteins and their annotated locations for NP_001258501.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI494060, AK001415, AK300978, AL360141, DA773492
    Consensus CDS
    CCDS61751.1
    UniProtKB/Swiss-Prot
    O75192
    UniProtKB/TrEMBL
    B2R8C6
    Related
    ENSP00000453492.1, ENST00000561257.1
    Conserved Domains (1) summary
    pfam05648
    Location:1206
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  2. NM_001271573.2NP_001258502.1  peroxisomal membrane protein 11A isoform 3

    See identical proteins and their annotated locations for NP_001258502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC013787, AI494060, AK001415, AK297442, AL360141
    UniProtKB/TrEMBL
    B2R8C6, B4DMF6
    Conserved Domains (1) summary
    pfam05648
    Location:4492
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  3. NM_003847.3NP_003838.1  peroxisomal membrane protein 11A isoform 1

    See identical proteins and their annotated locations for NP_003838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC013787, AI494060, AK001415, AL360141
    Consensus CDS
    CCDS10354.1
    UniProtKB/Swiss-Prot
    O75192
    UniProtKB/TrEMBL
    B2R8C6
    Related
    ENSP00000300056.3, ENST00000300056.8
    Conserved Domains (1) summary
    pfam05648
    Location:1237
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    89681535..89690754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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