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Per3 period circadian clock 3 [ Mus musculus (house mouse) ]

Gene ID: 18628, updated on 18-Oct-2022

Summary

Official Symbol
Per3provided by MGI
Official Full Name
period circadian clock 3provided by MGI
Primary source
MGI:MGI:1277134
See related
Ensembl:ENSMUSG00000028957 AllianceGenome:MGI:1277134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPer3; 2810049O06Rik
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Broad expression in bladder adult (RPKM 14.0), cortex adult (RPKM 6.1) and 22 other tissues See more
Orthologs
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Genomic context

See Per3 in Genome Data Viewer
Location:
4; 4 E2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (151081475..151129167, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150997018..151044707, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23405 Neighboring gene predicted gene, 30120 Neighboring gene urotensin 2 Neighboring gene predicted gene, 38529 Neighboring gene vesicle-associated membrane protein 3 Neighboring gene calmodulin binding transcription activator 1 Neighboring gene predicted gene 13090

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
period circadian protein homolog 3
Names
circadian clock protein PERIOD 3
period homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289877.1NP_001276806.1  period circadian protein homolog 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL607143
    Conserved Domains (3) summary
    cd00130
    Location:280372
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9081111
    Period_C; Period protein 2/3C-terminal region
  2. NM_001289878.1NP_001276807.1  period circadian protein homolog 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL607143
    Conserved Domains (1) summary
    pfam12114
    Location:701797
    Period_C; Period protein 2/3C-terminal region
  3. NM_011067.3NP_035197.2  period circadian protein homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_035197.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AL607143
    Consensus CDS
    CCDS18978.1
    UniProtKB/Swiss-Prot
    A2A894, O70361
    Related
    ENSMUSP00000099493.5, ENSMUST00000103204.11
    Conserved Domains (3) summary
    cd00130
    Location:280372
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9071110
    Period_C; Period protein 2/3C-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    151081475..151129167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163827.1XP_036019720.1  period circadian protein homolog 3 isoform X7

    Conserved Domains (2) summary
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:8641040
    Period_C; Period protein 2/3C-terminal region
  2. XM_017320034.3XP_017175523.2  period circadian protein homolog 3 isoform X4

    Conserved Domains (2) summary
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9051081
    Period_C; Period protein 2/3C-terminal region
  3. XM_017320032.3XP_017175521.1  period circadian protein homolog 3 isoform X2

    Conserved Domains (2) summary
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9061082
    Period_C; Period protein 2/3C-terminal region
  4. XM_017320033.3XP_017175522.1  period circadian protein homolog 3 isoform X3

    Conserved Domains (2) summary
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9061082
    Period_C; Period protein 2/3C-terminal region
  5. XM_017320031.3XP_017175520.1  period circadian protein homolog 3 isoform X1

    Conserved Domains (2) summary
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9071083
    Period_C; Period protein 2/3C-terminal region
  6. XM_030253311.2XP_030109171.1  period circadian protein homolog 3 isoform X8

    Conserved Domains (1) summary
    pfam12114
    Location:591767
    Period_C; Period protein 2/3C-terminal region
  7. XM_017320036.3XP_017175525.1  period circadian protein homolog 3 isoform X9

    Conserved Domains (1) summary
    pfam12114
    Location:588764
    Period_C; Period protein 2/3C-terminal region
  8. XM_036163826.1XP_036019719.1  period circadian protein homolog 3 isoform X6

    Conserved Domains (2) summary
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9051109
    Period_C; Period protein 2/3C-terminal region
  9. XM_011250203.4XP_011248505.1  period circadian protein homolog 3 isoform X5

    Conserved Domains (2) summary
    pfam08447
    Location:280368
    PAS_3; PAS fold
    pfam12114
    Location:9061110
    Period_C; Period protein 2/3C-terminal region

RNA

  1. XR_004941847.1 RNA Sequence

  2. XR_004941849.1 RNA Sequence

  3. XR_004941848.1 RNA Sequence

  4. XR_004941846.1 RNA Sequence

  5. XR_004941845.1 RNA Sequence

  6. XR_004941844.1 RNA Sequence

  7. XR_003954892.2 RNA Sequence

  8. XR_004941850.1 RNA Sequence

  9. XR_001784108.3 RNA Sequence

  10. XR_004941843.1 RNA Sequence