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Per2 period circadian clock 2 [ Mus musculus (house mouse) ]

Gene ID: 18627, updated on 5-Nov-2019

Summary

Official Symbol
Per2provided by MGI
Official Full Name
period circadian clock 2provided by MGI
Primary source
MGI:MGI:1195265
See related
Ensembl:ENSMUSG00000055866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPer2; mKIAA0347
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.3), bladder adult (RPKM 12.8) and 28 other tissues See more
Orthologs

Genomic context

See Per2 in Genome Data Viewer
Location:
1; 1 D
Exon count:
24
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91415977..91459351, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (93312559..93355905, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020N18 gene Neighboring gene hairy and enhancer of split 6 Neighboring gene predicted gene, 35591 Neighboring gene predicted gene 28382 Neighboring gene nucleolar complex associated 3 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
pre-mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-templated transcription, termination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glutamate uptake involved in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
period circadian protein homolog 2
Names
circadian clock protein PERIOD 2
period 2
period homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011066.3NP_035196.2  period circadian protein homolog 2

    See identical proteins and their annotated locations for NP_035196.2

    Status: VALIDATED

    Source sequence(s)
    AF035830, AF036893, AK044658, AK159847, BY315400
    Consensus CDS
    CCDS35663.1
    UniProtKB/Swiss-Prot
    O54943
    UniProtKB/TrEMBL
    A0A0R4J0U3, Q3TW41, Q8C8R0
    Related
    ENSMUSP00000066620.8, ENSMUST00000069620.9
    Conserved Domains (3) summary
    cd00130
    Location:330432
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:344428
    PAS_3; PAS fold
    pfam12114
    Location:10401234
    Period_C; Period protein 2/3C-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    91415977..91459351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529249.4XP_006529312.1  period circadian protein homolog 2 isoform X1

    Conserved Domains (3) summary
    cd00130
    Location:329431
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:343427
    PAS_3; PAS fold
    pfam12114
    Location:10391233
    Period_C; Period protein 2/3C-terminal region
  2. XM_006529250.4XP_006529313.1  period circadian protein homolog 2 isoform X2

    Conserved Domains (3) summary
    cd00130
    Location:189291
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:203287
    PAS_3; PAS fold
    pfam12114
    Location:8991093
    Period_C; Period protein 2/3C-terminal region
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