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Per2 period circadian clock 2 [ Mus musculus (house mouse) ]

Gene ID: 18627, updated on 19-Feb-2024

Summary

Official Symbol
Per2provided by MGI
Official Full Name
period circadian clock 2provided by MGI
Primary source
MGI:MGI:1195265
See related
Ensembl:ENSMUSG00000055866 AllianceGenome:MGI:1195265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPer2; mKIAA0347
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.3), bladder adult (RPKM 12.8) and 28 other tissues See more
Orthologs
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Genomic context

See Per2 in Genome Data Viewer
Location:
1 D; 1 46.13 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91343699..91387028, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91415977..91459351, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020N18 gene Neighboring gene STARR-positive B cell enhancer ABC_E5783 Neighboring gene hairy and enhancer of split 6 Neighboring gene predicted gene, 35591 Neighboring gene STARR-positive B cell enhancer ABC_E986 Neighboring gene predicted gene 28382 Neighboring gene nucleolar complex associated 3 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pre-mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lactate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of termination of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glutamate uptake involved in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
period circadian protein homolog 2
Names
circadian clock protein PERIOD 2
period 2
period homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420881.1NP_001407810.1  period circadian protein homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109199, AC110510
    UniProtKB/TrEMBL
    Q3TN36
  2. NM_011066.4NP_035196.2  period circadian protein homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_035196.2

    Status: VALIDATED

    Source sequence(s)
    AC109199, AC110510
    Consensus CDS
    CCDS35663.1
    UniProtKB/TrEMBL
    A0A0R4J0U3, Q3TN36
    Related
    ENSMUSP00000066620.9, ENSMUST00000069620.10
    Conserved Domains (3) summary
    cd00130
    Location:330432
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:344428
    PAS_3; PAS fold
    pfam12114
    Location:10401234
    Period_C; Period protein 2/3C-terminal region

RNA

  1. NR_185210.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC109199, AC110510

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    91343699..91387028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529250.5XP_006529313.1  period circadian protein homolog 2 isoform X2

    UniProtKB/TrEMBL
    Q3TN36
    Conserved Domains (4) summary
    PHA03247
    Location:649897
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:304841
    PRK10263; DNA translocase FtsK; Provisional
    pfam08447
    Location:203287
    PAS_3; PAS fold
    pfam12114
    Location:8991093
    Period_C; Period protein 2/3C-terminal region