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Pecam1 platelet/endothelial cell adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 18613, updated on 23-Nov-2021

Summary

Official Symbol
Pecam1provided by MGI
Official Full Name
platelet/endothelial cell adhesion molecule 1provided by MGI
Primary source
MGI:MGI:97537
See related
Ensembl:ENSMUSG00000020717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd31; Pecam; C85791; PECAM-1
Expression
Broad expression in lung adult (RPKM 94.3), subcutaneous fat pad adult (RPKM 41.1) and 17 other tissues See more
Orthologs
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Genomic context

See Pecam1 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106545039..106606107, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106654213..106715281, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106515532..106576595, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22711 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene testis expressed gene 2 Neighboring gene predicted gene, 51950 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Polg2

Homology

Clone Names

  • MGC102160

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in diapedesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in smooth muscle contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
platelet endothelial cell adhesion molecule

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032378.2NP_001027550.1  platelet endothelial cell adhesion molecule isoform 2 precursor

    See identical proteins and their annotated locations for NP_001027550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 3' coding exon but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK169431, BC085502, BE692027, BY781761
    Consensus CDS
    CCDS25558.1
    UniProtKB/Swiss-Prot
    Q08481
    Related
    ENSMUSP00000099358.4, ENSMUST00000103069.10
    Conserved Domains (3) summary
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:317393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  2. NM_001305157.1NP_001292086.1  platelet endothelial cell adhesion molecule isoform 3 precursor

    See identical proteins and their annotated locations for NP_001292086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' coding exon, which results in a frameshift, compared to variant 1. It encodes isoform 3 which has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK084527, AK169431, BE692027, BY781761
    Consensus CDS
    CCDS79069.1
    UniProtKB/Swiss-Prot
    Q08481
    Related
    ENSMUSP00000102408.3, ENSMUST00000106796.9
    Conserved Domains (3) summary
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:317393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  3. NM_001305158.1NP_001292087.1  platelet endothelial cell adhesion molecule isoform 4 precursor

    See identical proteins and their annotated locations for NP_001292087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame 5' coding exon, and contains an alternate 3' coding exon which results in a frameshift, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK037551, AK084527, AK169431, BE692027, BY781761
    Consensus CDS
    CCDS79068.1
    UniProtKB/Swiss-Prot
    Q08481
    UniProtKB/TrEMBL
    Q8CAW4
    Related
    ENSMUSP00000138959.2, ENSMUST00000183610.8
    Conserved Domains (4) summary
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam00635
    Location:85185
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam13895
    Location:216292
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  4. NM_008816.3NP_032842.2  platelet endothelial cell adhesion molecule isoform 1 precursor

    See identical proteins and their annotated locations for NP_032842.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK084527, BE692027, BY781761
    Consensus CDS
    CCDS25559.1
    UniProtKB/Swiss-Prot
    Q08481
    Related
    ENSMUSP00000079664.5, ENSMUST00000080853.11
    Conserved Domains (3) summary
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:317393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106545039..106606107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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