Format

Send to:

Choose Destination

PECAM1 platelet and endothelial cell adhesion molecule 1 [ Homo sapiens (human) ]

Gene ID: 5175, updated on 1-Aug-2020

Summary

Official Symbol
PECAM1provided by HGNC
Official Full Name
platelet and endothelial cell adhesion molecule 1provided by HGNC
Primary source
HGNC:HGNC:8823
See related
Ensembl:ENSG00000261371 MIM:173445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
Summary
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Expression
Broad expression in placenta (RPKM 145.1), lung (RPKM 87.5) and 19 other tissues See more
Orthologs

Genomic context

See PECAM1 in Genome Data Viewer
Location:
17q23.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (64319415..64413844, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62396775..62404856, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene testis expressed 2 Neighboring gene ribosomal protein L31 pseudogene 57 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene ATP synthase membrane subunit f pseudogene 4 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of platelet/endothelial cell adhesion molecule 1 (PECAM1, PECA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34100, FLJ58394

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell recognition TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
diapedesis IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endothelial cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
glomerular endothelium development IEP
Inferred from Expression Pattern
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
maintenance of permeability of blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
monocyte extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
neutrophil extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell contact zone IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule membrane TAS
Traceable Author Statement
more info
 
smooth muscle contractile fiber IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
platelet endothelial cell adhesion molecule
Names
CD31 antigen
platelet endothelial cell adhesion molecule-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047009.1 RefSeqGene

    Range
    27942..99387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000442.5NP_000433.4  platelet endothelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_000433.4

    Status: REVIEWED

    Source sequence(s)
    AC016489, AF281298, BC051822
    Consensus CDS
    CCDS74132.1
    UniProtKB/Swiss-Prot
    P16284
    UniProtKB/TrEMBL
    A0A075B738
    Related
    ENSP00000457421.1, ENST00000563924.6
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    64319415..64413844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524889.2XP_011523191.1  platelet endothelial cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_011523191.1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  2. XM_017024740.1XP_016880229.1  platelet endothelial cell adhesion molecule isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  3. XM_011524890.1XP_011523192.1  platelet endothelial cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_011523192.1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  4. XM_017024738.1XP_016880227.1  platelet endothelial cell adhesion molecule isoform X1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  5. XM_017024741.1XP_016880230.1  platelet endothelial cell adhesion molecule isoform X7

  6. XM_017024739.1XP_016880228.1  platelet endothelial cell adhesion molecule isoform X3

  7. XM_005276882.1XP_005276939.1  platelet endothelial cell adhesion molecule isoform X5

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  8. XM_005276881.1XP_005276938.1  platelet endothelial cell adhesion molecule isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  9. XM_005276880.1XP_005276937.1  platelet endothelial cell adhesion molecule isoform X2

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  10. XM_005276883.2XP_005276940.1  platelet endothelial cell adhesion molecule isoform X6

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
Support Center