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PECAM1 platelet and endothelial cell adhesion molecule 1 [ Homo sapiens (human) ]

Gene ID: 5175, updated on 8-Jul-2018
Official Symbol
PECAM1provided by HGNC
Official Full Name
platelet and endothelial cell adhesion molecule 1provided by HGNC
Primary source
HGNC:HGNC:8823
See related
Ensembl:ENSG00000261371 MIM:173445; Vega:OTTHUMG00000175829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
Summary
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Expression
Broad expression in placenta (RPKM 145.1), lung (RPKM 87.5) and 19 other tissues See more
Orthologs
See PECAM1 in Genome Data Viewer
Location:
17q23.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (64319415..64413844, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62396775..62404856, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene testis expressed 2 Neighboring gene ribosomal protein L31 pseudogene 57 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene ATP synthase membrane subunit f pseudogene 4 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of platelet/endothelial cell adhesion molecule 1 (PECAM1, PECA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • PECAM1 interactions, organism-specific biosystem (from REACTOME)
    PECAM1 interactions, organism-specific biosystemPECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activ...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
  • Platelet sensitization by LDL, organism-specific biosystem (from REACTOME)
    Platelet sensitization by LDL, organism-specific biosystemPhysiological concentrations (1g/L) of Low density lipoprotein (LDL) enhance platelet aggregation responses initiated by thrombin, collagen, and ADP. This enhancement involves the rapid phosphorylati...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ34100, FLJ58394

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell recognition TAS
Traceable Author Statement
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
diapedesis IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
glomerular endothelium development IEP
Inferred from Expression Pattern
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
neutrophil extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
Preferred Names
platelet endothelial cell adhesion molecule
Names
CD31 antigen
platelet endothelial cell adhesion molecule-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047009.1 RefSeqGene

    Range
    27924..99387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000442.4NP_000433.4  platelet endothelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_000433.4

    Status: REVIEWED

    Source sequence(s)
    AC016489, AF281298, BC051822
    Consensus CDS
    CCDS74132.1
    UniProtKB/Swiss-Prot
    P16284
    UniProtKB/TrEMBL
    A0A075B738
    Related
    ENSP00000457421.1, OTTHUMP00000254150, ENST00000563924.5, OTTHUMT00000431142
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    64319415..64413844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524889.2XP_011523191.1  platelet endothelial cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_011523191.1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  2. XM_017024740.1XP_016880229.1  platelet endothelial cell adhesion molecule isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  3. XM_011524890.1XP_011523192.1  platelet endothelial cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_011523192.1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  4. XM_017024738.1XP_016880227.1  platelet endothelial cell adhesion molecule isoform X1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  5. XM_017024741.1XP_016880230.1  platelet endothelial cell adhesion molecule isoform X7

  6. XM_017024739.1XP_016880228.1  platelet endothelial cell adhesion molecule isoform X3

  7. XM_005276882.1XP_005276939.1  platelet endothelial cell adhesion molecule isoform X5

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  8. XM_005276881.1XP_005276938.1  platelet endothelial cell adhesion molecule isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  9. XM_005276880.1XP_005276937.1  platelet endothelial cell adhesion molecule isoform X2

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  10. XM_005276883.2XP_005276940.1  platelet endothelial cell adhesion molecule isoform X6

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
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