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PECAM1 platelet and endothelial cell adhesion molecule 1 [ Homo sapiens (human) ]

Gene ID: 5175, updated on 8-Jul-2021

Summary

Official Symbol
PECAM1provided by HGNC
Official Full Name
platelet and endothelial cell adhesion molecule 1provided by HGNC
Primary source
HGNC:HGNC:8823
See related
Ensembl:ENSG00000261371 MIM:173445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
Summary
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Expression
Broad expression in placenta (RPKM 145.1), lung (RPKM 87.5) and 19 other tissues See more
Orthologs
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Genomic context

See PECAM1 in Genome Data Viewer
Location:
17q23.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (64319415..64413844, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62396775..62404854, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene testis expressed 2 Neighboring gene ribosomal protein L31 pseudogene 57 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene ATP synthase membrane subunit f pseudogene 4 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of platelet/endothelial cell adhesion molecule 1 (PECAM1, PECA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34100, FLJ58394

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell recognition TAS
Traceable Author Statement
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in diapedesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glomerular endothelium development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
involved_in monocyte extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
platelet endothelial cell adhesion molecule
Names
CD31 antigen
platelet endothelial cell adhesion molecule-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047009.1 RefSeqGene

    Range
    27942..99387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000442.5NP_000433.4  platelet endothelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_000433.4

    Status: REVIEWED

    Source sequence(s)
    AC016489, AF281298, BC051822
    Consensus CDS
    CCDS74132.1
    UniProtKB/Swiss-Prot
    P16284
    UniProtKB/TrEMBL
    A0A075B738
    Related
    ENSP00000457421.1, ENST00000563924.6
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    64319415..64413844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524889.2XP_011523191.1  platelet endothelial cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_011523191.1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  2. XM_017024740.1XP_016880229.1  platelet endothelial cell adhesion molecule isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  3. XM_011524890.1XP_011523192.1  platelet endothelial cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_011523192.1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  4. XM_017024738.1XP_016880227.1  platelet endothelial cell adhesion molecule isoform X1

    UniProtKB/TrEMBL
    A0A075B738
    Conserved Domains (2) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:327404
    Ig_2; Immunoglobulin domain
  5. XM_017024741.1XP_016880230.1  platelet endothelial cell adhesion molecule isoform X7

  6. XM_017024739.1XP_016880228.1  platelet endothelial cell adhesion molecule isoform X3

  7. XM_005276882.1XP_005276939.1  platelet endothelial cell adhesion molecule isoform X5

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  8. XM_005276881.1XP_005276938.1  platelet endothelial cell adhesion molecule isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  9. XM_005276880.1XP_005276937.1  platelet endothelial cell adhesion molecule isoform X2

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
  10. XM_005276883.2XP_005276940.1  platelet endothelial cell adhesion molecule isoform X6

    Conserved Domains (4) summary
    smart00410
    Location:43127
    IG_like; Immunoglobulin like
    pfam13895
    Location:328404
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:507576
    Ig_3; Immunoglobulin domain
    cl11960
    Location:43127
    Ig; Immunoglobulin domain
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