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Pdha2 pyruvate dehydrogenase E1 alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 18598, updated on 1-Mar-2024

Summary

Official Symbol
Pdha2provided by MGI
Official Full Name
pyruvate dehydrogenase E1 alpha 2provided by MGI
Primary source
MGI:MGI:97533
See related
Ensembl:ENSMUSG00000047674 AllianceGenome:MGI:97533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdhal
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in nervous system and testis. Orthologous to human PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Pdha2 in Genome Data Viewer
Location:
3 H1; 3 65.3 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (140915765..140918116, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (141210004..141212355, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09142 Neighboring gene RIKEN cDNA 4930590L14 gene Neighboring gene predicted gene, 32754 Neighboring gene STARR-seq mESC enhancer starr_09143 Neighboring gene predicted gene, 32875 Neighboring gene STARR-seq mESC enhancer starr_09144 Neighboring gene STARR-seq mESC enhancer starr_09145 Neighboring gene unc-5 netrin receptor C Neighboring gene predicted gene 15689 Neighboring gene STARR-seq mESC enhancer starr_09146 Neighboring gene STARR-seq mESC enhancer starr_09149 Neighboring gene STARR-seq mESC enhancer starr_09150 Neighboring gene bone morphogenetic protein receptor, type 1B Neighboring gene STARR-seq mESC enhancer starr_09151

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of dihydrolipoyl dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Names
PDHE1-A type II
PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT, TESTIS-SPECIFIC FORM, MITOCHONDRIAL PRECURSOR (PDHE1-A TYPE II)
NP_032837.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008811.2NP_032837.1  pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032837.1

    Status: VALIDATED

    Source sequence(s)
    AC100752
    Consensus CDS
    CCDS17872.1
    UniProtKB/Swiss-Prot
    P35487, Q497M8
    UniProtKB/TrEMBL
    Q9D9X9
    Related
    ENSMUSP00000060774.3, ENSMUST00000057860.3
    Conserved Domains (1) summary
    TIGR03182
    Location:59371
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    140915765..140918116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)