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PDHA2 pyruvate dehydrogenase E1 subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 5161, updated on 21-Dec-2019

Summary

Official Symbol
PDHA2provided by HGNC
Official Full Name
pyruvate dehydrogenase E1 subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:8807
See related
Ensembl:ENSG00000163114 MIM:179061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDHAL
Orthologs

Genomic context

See PDHA2 in Genome Data Viewer
Location:
4q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (95840093..95841464)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (96761239..96762625)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377337 Neighboring gene ribosomal protein L30 pseudogene 6 Neighboring gene RNA, U6 small nuclear 1059, pseudogene Neighboring gene RNA, U6 small nuclear 34, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149517, MGC149518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
pyruvate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
pyruvate dehydrogenase (acetyl-transferring) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
pyruvate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
pyruvate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Names
PDHE1-A type II
pyruvate dehydrogenase (lipoamide) alpha 2
pyruvate dehydrogenase E1 alpha 2 subunit
pyruvate dehydrogenase alpha 2
pyruvate dehydrogenase, E1-alpha polypeptide, testis specific
NP_005381.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005390.5NP_005381.1  pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_005381.1

    Status: VALIDATED

    Source sequence(s)
    BC030697
    Consensus CDS
    CCDS3644.1
    UniProtKB/Swiss-Prot
    P29803
    Related
    ENSP00000295266.4, ENST00000295266.6
    Conserved Domains (1) summary
    TIGR03182
    Location:56368
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    95840093..95841464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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