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DVL2 dishevelled segment polarity protein 2 [ Homo sapiens (human) ]

Gene ID: 1856, updated on 5-Jul-2020

Summary

Official Symbol
DVL2provided by HGNC
Official Full Name
dishevelled segment polarity protein 2provided by HGNC
Primary source
HGNC:HGNC:3086
See related
Ensembl:ENSG00000004975 MIM:602151
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 14.8), endometrium (RPKM 11.4) and 25 other tissues See more
Orthologs

Genomic context

See DVL2 in Genome Data Viewer
Location:
17p13.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7225341..7234544, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7128661..7137867, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene acyl-CoA dehydrogenase very long chain Neighboring gene microRNA 324 Neighboring gene PHD finger protein 23 Neighboring gene GABA type A receptor-associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rac GTPase binding IEA
Inferred from Electronic Annotation
more info
 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
frizzled binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein self-association IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway involved in regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cochlea morphogenesis IEA
Inferred from Electronic Annotation
more info
 
convergent extension involved in neural plate elongation IEA
Inferred from Electronic Annotation
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
hippo signaling TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
non-canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
planar cell polarity pathway involved in neural tube closure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
segment specification ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
aggresome IDA
Inferred from Direct Assay
more info
 
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated endocytic vesicle TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
segment polarity protein dishevelled homolog DVL-2
Names
dishevelled 2 (homologous to Drosophila dsh)
dishevelled, dsh homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033038.1 RefSeqGene

    Range
    5028..14203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004422.3NP_004413.1  segment polarity protein dishevelled homolog DVL-2

    See identical proteins and their annotated locations for NP_004413.1

    Status: REVIEWED

    Source sequence(s)
    AK026019, BC014844, BG716400, CB994349
    Consensus CDS
    CCDS11091.1
    UniProtKB/Swiss-Prot
    O14641
    Related
    ENSP00000005340.4, ENST00000005340.10
    Conserved Domains (5) summary
    smart00021
    Location:1393
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7225341..7234544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256502.2XP_005256559.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    Conserved Domains (5) summary
    smart00021
    Location:1393
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RNA

  1. XR_001752442.2 RNA Sequence

  2. XR_001752443.2 RNA Sequence

  3. XR_001752441.2 RNA Sequence

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