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Dvl2 dishevelled segment polarity protein 2 [ Mus musculus (house mouse) ]

Gene ID: 13543, updated on 8-Feb-2024

Summary

Official Symbol
Dvl2provided by MGI
Official Full Name
dishevelled segment polarity protein 2provided by MGI
Primary source
MGI:MGI:106613
See related
Ensembl:ENSMUSG00000020888 AllianceGenome:MGI:106613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables several functions, including enzyme binding activity; frizzled binding activity; and identical protein binding activity. Involved in several processes, including outflow tract morphogenesis; positive regulation of GTPase activity; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of protein tyrosine kinase activity; and segment specification. Located in several cellular components, including apical part of cell; clathrin-coated vesicle; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and retina. Used to study dextro-looped transposition of the great arteries. Orthologous to human DVL2 (dishevelled segment polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.1), thymus adult (RPKM 11.5) and 28 other tissues See more
Orthologs
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Genomic context

See Dvl2 in Genome Data Viewer
Location:
11 B3; 11 42.96 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69891418..69900935)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70000592..70010109)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2997 Neighboring gene gamma-aminobutyric acid receptor associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69808904-69809245 Neighboring gene PHD finger protein 23 Neighboring gene acyl-Coenzyme A dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene STARR-positive B cell enhancer ABC_E11483 Neighboring gene STARR-positive B cell enhancer ABC_E1421 Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E2358

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in neural plate elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in neural plate elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in organogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in planar cell polarity pathway involved in neural tube closure IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within segment specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in segmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
segment polarity protein dishevelled homolog DVL-2
Names
DSH homolog 2
dishevelled 2, dsh homolog
dishevelled-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007888.4NP_031914.3  segment polarity protein dishevelled homolog DVL-2

    See identical proteins and their annotated locations for NP_031914.3

    Status: VALIDATED

    Source sequence(s)
    AL596185
    Consensus CDS
    CCDS24930.1
    UniProtKB/Swiss-Prot
    Q60838, Q7TN14
    UniProtKB/TrEMBL
    I6L9H1
    Related
    ENSMUSP00000019362.9, ENSMUST00000019362.15
    Conserved Domains (5) summary
    smart00021
    Location:1393
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69891418..69900935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)