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Furin furin (paired basic amino acid cleaving enzyme) [ Mus musculus (house mouse) ]

Gene ID: 18550, updated on 11-Mar-2018

Summary

Official Symbol
Furinprovided by MGI
Official Full Name
furin (paired basic amino acid cleaving enzyme)provided by MGI
Primary source
MGI:MGI:97513
See related
Ensembl:ENSMUSG00000030530 Vega:OTTMUSG00000028566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fur; PACE; SPC1; Pcsk3; 9130404I01Rik
Summary
This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Broad expression in stomach adult (RPKM 243.5), adrenal adult (RPKM 89.1) and 15 other tissues See more
Orthologs

Genomic context

See Furin in Genome Data Viewer
Location:
7 D2; 7 45.65 cM
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (80389194..80405441, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (87534080..87550317, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene mannosidase 2, alpha 2 Neighboring gene feline sarcoma oncogene Neighboring gene serine hydroxymethyltransferase 2 pseudogene Neighboring gene Bloom syndrome, RecQ like helicase Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
dibasic protein processing ISO
Inferred from Sequence Orthology
more info
 
negative regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
nerve growth factor production ISO
Inferred from Sequence Orthology
more info
 
peptide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein processing IDA
Inferred from Direct Assay
more info
PubMed 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein processing ISO
Inferred from Sequence Orthology
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of low-density lipoprotein particle receptor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
secretion by cell ISO
Inferred from Sequence Orthology
more info
 
signal peptide processing ISO
Inferred from Sequence Orthology
more info
 
zymogen activation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi cisterna ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
early endosome TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
trans-Golgi network transport vesicle membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
furin
Names
dibasic-processing enzyme
paired basic amino acid residue cleaving enzyme
prohormone convertase 3
proprotein convertase subtilisin/kexin type 3
subtilisin pro-protein processing enzyme
NP_001074923.1
NP_035176.1
XP_011249120.1
XP_011249121.1
XP_011249122.1
XP_011249123.1
XP_011249124.1
XP_011249125.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081454.2NP_001074923.1  furin preproprotein

    See identical proteins and their annotated locations for NP_001074923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136740
    Consensus CDS
    CCDS21397.1
    UniProtKB/Swiss-Prot
    P23188
    Related
    ENSMUSP00000102985.3, ENSMUST00000107362.9
    Conserved Domains (5) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam00082
    Location:144427
    Peptidase_S8; Subtilase family
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  2. NM_011046.3NP_035176.1  furin preproprotein

    See identical proteins and their annotated locations for NP_035176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136740
    Consensus CDS
    CCDS21397.1
    UniProtKB/Swiss-Prot
    P23188
    Related
    ENSMUSP00000113370.1, OTTMUSP00000036135, ENSMUST00000122232.7, OTTMUST00000070797
    Conserved Domains (5) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam00082
    Location:144427
    Peptidase_S8; Subtilase family
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    80389194..80405441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250821.2XP_011249123.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249123.1

    Conserved Domains (5) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam00082
    Location:144437
    Peptidase_S8; Subtilase family
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  2. XM_011250822.2XP_011249124.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249124.1

    Conserved Domains (5) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam00082
    Location:144437
    Peptidase_S8; Subtilase family
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  3. XM_011250819.2XP_011249121.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249121.1

    Conserved Domains (5) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam00082
    Location:144437
    Peptidase_S8; Subtilase family
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  4. XM_011250818.1XP_011249120.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249120.1

    Conserved Domains (5) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam00082
    Location:144437
    Peptidase_S8; Subtilase family
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  5. XM_011250820.2XP_011249122.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249122.1

    Conserved Domains (5) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam00082
    Location:144437
    Peptidase_S8; Subtilase family
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  6. XM_011250823.1XP_011249125.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249125.1

    Conserved Domains (5) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam00082
    Location:144437
    Peptidase_S8; Subtilase family
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
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