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Furin furin, paired basic amino acid cleaving enzyme [ Mus musculus (house mouse) ]

Gene ID: 18550, updated on 27-Feb-2024

Summary

Official Symbol
Furinprovided by MGI
Official Full Name
furin, paired basic amino acid cleaving enzymeprovided by MGI
Primary source
MGI:MGI:97513
See related
Ensembl:ENSMUSG00000030530 AllianceGenome:MGI:97513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fur; PACE; SPC1; Pcsk3; 9130404I01Rik
Summary
This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Broad expression in stomach adult (RPKM 243.5), adrenal adult (RPKM 89.1) and 15 other tissues See more
Orthologs
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Genomic context

See Furin in Genome Data Viewer
Location:
7 D2; 7 45.65 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80038942..80055188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80389194..80405441, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene HD domain containing 3 Neighboring gene mannosidase 2, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene feline sarcoma oncogene Neighboring gene predicted gene 44851 Neighboring gene serine hydroxymethyltransferase 2 pseudogene Neighboring gene VISTA enhancer mm169 Neighboring gene Bloom syndrome, RecQ like helicase Neighboring gene STARR-seq mESC enhancer starr_19328 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in blastocyst formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytokine precursor processing ISO
Inferred from Sequence Orthology
more info
 
involved_in dibasic protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein processing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in secretion by cell ISO
Inferred from Sequence Orthology
more info
 
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
 
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in zymogen inhibition ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in trans-Golgi network transport vesicle membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
furin
Names
dibasic-processing enzyme
paired basic amino acid residue cleaving enzyme
prohormone convertase 3
proprotein convertase subtilisin/kexin type 3
subtilisin pro-protein processing enzyme
NP_001074923.1
NP_035176.1
XP_011249120.1
XP_011249121.1
XP_011249122.1
XP_011249123.1
XP_011249124.1
XP_011249125.1
XP_030098069.1
XP_030098070.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081454.2NP_001074923.1  furin preproprotein

    See identical proteins and their annotated locations for NP_001074923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136740
    Consensus CDS
    CCDS21397.1
    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Related
    ENSMUSP00000102985.4, ENSMUST00000107362.10
    Conserved Domains (4) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  2. NM_011046.3NP_035176.1  furin preproprotein

    See identical proteins and their annotated locations for NP_035176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136740
    Consensus CDS
    CCDS21397.1
    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Related
    ENSMUSP00000113370.2, ENSMUST00000122232.8
    Conserved Domains (4) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80038942..80055188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250821.3XP_011249123.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249123.1

    Conserved Domains (4) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  2. XM_011250822.3XP_011249124.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249124.1

    Conserved Domains (4) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  3. XM_011250819.4XP_011249121.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249121.1

    Conserved Domains (4) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  4. XM_011250818.2XP_011249120.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249120.1

    Conserved Domains (4) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  5. XM_030242209.2XP_030098069.1  furin isoform X2

    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Conserved Domains (4) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  6. XM_011250820.4XP_011249122.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249122.1

    Conserved Domains (4) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  7. XM_030242210.2XP_030098070.1  furin isoform X2

    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Conserved Domains (4) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  8. XM_011250823.1XP_011249125.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249125.1

    Conserved Domains (4) summary
    cd04059
    Location:113412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648685
    FU; Furin-like repeats
    pfam01483
    Location:494580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain