Pcp4 Purkinje cell protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcp4provided by MGI
Official Full Name: Purkinje cell protein 4provided by MGI
Primary source: MGI:MGI:97509
See related: Ensembl:ENSMUSG00000090223 AllianceGenome:MGI:97509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcp-4; Pep19; P16Rimb19
Summary: Enables calmodulin binding activity. Predicted to be involved in several processes, including calmodulin dependent kinase signaling pathway; negative regulation of protein kinase activity; and positive regulation of dopamine secretion. Predicted to be located in axon and neurofilament. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Orthologous to human PCP4 (Purkinje cell protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 246.2), frontal lobe adult (RPKM 161.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 56.97 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (96268806..96326993)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (96467606..96525793)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice.
Title: Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice.
Airway Ciliary Beating Affected by the Pcp4 Dose-Dependent [Ca(2+)]i Increase in Down Syndrome Mice, Ts1Rhr.
Title: Airway Ciliary Beating Affected by the Pcp4 Dose-Dependent [Ca(2+)](i) Increase in Down Syndrome Mice, Ts1Rhr.
PEP-19/pcp4 has previously been identified as a critical determinant of synaptic plasticity.
Title: MS imaging and mass spectrometric synaptosome profiling identify PEP-19/pcp4 as a synaptic molecule involved in spatial learning in mice.
We further found that Pcp4 gene on the Ts1Rhr trisomic segment is expressed in ependymal cells, and its resumption to two copies rescued both ventricular enlargement and cilia dysfunction in Ts1Rhr mice.
Title: Brain ventriculomegaly in Down syndrome mice is caused by Pcp4 dose-dependent cilia dysfunction.
PCP4 regulates cardiac excitability through both Purkinje cell-autonomous and central mechanisms.
Title: PCP4 regulates Purkinje cell excitability and cardiac rhythmicity.
The PCP4 immunostaining-delineated CA2 neurons have distinguishable differences in cell morphology, physiology, and synaptic circuit connections compared with distal CA3 and proximal CA1 regions.
Title: Distinct physiological and developmental properties of hippocampal CA2 subfield revealed by using anti-Purkinje cell protein 4 (PCP4) immunostaining.
Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch.
Title: Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.
Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation.
Title: PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.
Data indicate that pep-19/pcp4 is a critical determinant of synaptic plasticity in cerebellum and locomotor learning.
Title: Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice.
The expression of Pcp4 in naive resting mature B cells is dependent upon tonic stimulation from the CR1/CR2 proteins via a C3 ligand.
Title: CD21 signaling via C3 regulates Purkinje cell protein 4 expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Pcp4 (e-PCR), detects polymorphism
- UniSTS:144141

Pcp4 (e-PCR), detects polymorphism
- UniSTS:144142

Pcp4 (e-PCR), detects polymorphism
- UniSTS:259125

Pcp4 (e-PCR), detects polymorphism
- UniSTS:259645

Pcp4 (e-PCR), detects polymorphism
- UniSTS:461898

G67846 (e-PCR)
- UniSTS:228493

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calmodulin dependent kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in neurofilament	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calmodulin regulator protein PCP4

Names: brain-specific antigen PCP-4; brain-specific polypeptide PEP-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.