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Pcp4 Purkinje cell protein 4 [ Mus musculus (house mouse) ]

Gene ID: 18546, updated on 18-Apr-2024

Summary

Official Symbol
Pcp4provided by MGI
Official Full Name
Purkinje cell protein 4provided by MGI
Primary source
MGI:MGI:97509
See related
Ensembl:ENSMUSG00000090223 AllianceGenome:MGI:97509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcp-4; Pep19; P16Rimb19
Summary
Enables calmodulin binding activity. Predicted to be involved in several processes, including calmodulin dependent kinase signaling pathway; negative regulation of protein kinase activity; and positive regulation of dopamine secretion. Predicted to be located in axon and neurofilament. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Orthologous to human PCP4 (Purkinje cell protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 246.2), frontal lobe adult (RPKM 161.1) and 5 other tissues See more
Orthologs
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Genomic context

Location:
16 C4; 16 56.97 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (96268806..96326993)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (96467606..96525793)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41510 Neighboring gene immunoglobulin superfamily, member 5 Neighboring gene STARR-seq mESC enhancer starr_41621 Neighboring gene integrin beta 2-like Neighboring gene STARR-positive B cell enhancer ABC_E8916 Neighboring gene DS cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_41622 Neighboring gene predicted gene, 32509 Neighboring gene VISTA enhancer mm1636 Neighboring gene predicted gene, 32432

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neurofilament ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calmodulin regulator protein PCP4
Names
brain-specific antigen PCP-4
brain-specific polypeptide PEP-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008791.3NP_032817.1  calmodulin regulator protein PCP4

    See identical proteins and their annotated locations for NP_032817.1

    Status: VALIDATED

    Source sequence(s)
    BC061164, CB523728
    Consensus CDS
    CCDS37414.1
    UniProtKB/Swiss-Prot
    P63054
    Related
    ENSMUSP00000062539.9, ENSMUST00000061739.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    96268806..96326993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)