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PLoS One. 2013 May 9;8(5):e63160. doi: 10.1371/journal.pone.0063160. Print 2013.

Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.

Author information

1
Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

Abstract

Branchial arches are externally visible tissue bands in the head region of all vertebrate embryos. Although initially formed from similar components, each arch will give rise to different head and neck structures. In a screen designed to characterize the molecular control of branchial arch identity in mouse, we identified Pcp4 as a second branchial arch-specific molecular signature. We further show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch. Hoxa2 is also sufficient to induce Pcp4 expression in anterior first arch cells, which are Pcp4-negative.

PMID:
23671666
PMCID:
PMC3650044
DOI:
10.1371/journal.pone.0063160
[Indexed for MEDLINE]
Free PMC Article
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