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DUSP4 dual specificity phosphatase 4 [ Homo sapiens (human) ]

Gene ID: 1846, updated on 21-Dec-2019

Summary

Official Symbol
DUSP4provided by HGNC
Official Full Name
dual specificity phosphatase 4provided by HGNC
Primary source
HGNC:HGNC:3070
See related
Ensembl:ENSG00000120875 MIM:602747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TYP; HVH2; MKP2; MKP-2
Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 8.5), gall bladder (RPKM 5.0) and 19 other tissues See more
Orthologs

Genomic context

See DUSP4 in Genome Data Viewer
Location:
8p12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (29333062..29350684, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29190579..29208267, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 13B Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene uncharacterized LOC105379349 Neighboring gene uncharacterized LOC107986883

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Primary human Muller glia cells treated with HIV-1 clade B Tat, but not with clade C Tat, upregulate the expression of MKP-2 protein PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
inactivation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inactivation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 4
Names
MAP kinase phosphatase 2
VH1 homologous phosphatase 2
dual specificity protein phosphatase hVH2
mitogen-activated protein kinase phosphatase 2
serine/threonine specific protein phosphatase
NP_001385.1
NP_476499.1
XP_011542730.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394.7NP_001385.1  dual specificity protein phosphatase 4 isoform 1

    See identical proteins and their annotated locations for NP_001385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AC084262, AK314820, AL137704, BC012900, DA645190
    Consensus CDS
    CCDS6072.1
    UniProtKB/Swiss-Prot
    Q13115
    Related
    ENSP00000240100.2, ENST00000240100.7
    Conserved Domains (2) summary
    cd00127
    Location:195331
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:9158
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
  2. NM_057158.3NP_476499.1  dual specificity protein phosphatase 4 isoform 2

    See identical proteins and their annotated locations for NP_476499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084262, AI123616, AL137704, BC012900
    Consensus CDS
    CCDS6073.1
    UniProtKB/Swiss-Prot
    Q13115
    Related
    ENSP00000240101.2, ENST00000240101.2
    Conserved Domains (1) summary
    cd00127
    Location:104240
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    29333062..29350684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544428.3XP_011542730.1  dual specificity protein phosphatase 4 isoform X1

    See identical proteins and their annotated locations for XP_011542730.1

    UniProtKB/Swiss-Prot
    Q13115
    Conserved Domains (1) summary
    cd00127
    Location:104240
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
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