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Osmr oncostatin M receptor [ Mus musculus (house mouse) ]

Gene ID: 18414, updated on 8-Feb-2024

Summary

Official Symbol
Osmrprovided by MGI
Official Full Name
oncostatin M receptorprovided by MGI
Primary source
MGI:MGI:1330819
See related
Ensembl:ENSMUSG00000022146 AllianceGenome:MGI:1330819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OSMRB
Summary
Enables cytokine binding activity and oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cell surface receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; hemolymphoid system; lung; sensory organ; and skeletal system. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 9.5), subcutaneous fat pad adult (RPKM 5.8) and 18 other tissues See more
Orthologs
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Genomic context

See Osmr in Genome Data Viewer
Location:
15 A1; 15 3.3 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6843049..6904434, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6813568..6874968, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene FYN binding protein 1 Neighboring gene predicted gene 2245 Neighboring gene STARR-seq mESC enhancer starr_37866 Neighboring gene prohibitin pseudogene Neighboring gene STARR-seq mESC enhancer starr_37870 Neighboring gene RPTOR independent companion of MTOR, complex 2 Neighboring gene predicted gene, 53882 Neighboring gene STARR-seq mESC enhancer starr_37871 Neighboring gene STARR-seq mESC enhancer starr_37872 Neighboring gene predicted gene, 41261 Neighboring gene predicted gene, 30559 Neighboring gene predicted gene, 30663

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ciliary neurotrophic factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables oncostatin-M receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to oncostatin-M receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of oncostatin-M receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
oncostatin-M-specific receptor subunit beta
Names
IL-31 receptor subunit beta
IL-31R subunit beta
IL-31R-beta
IL-31RB
interleukin-31 receptor subunit beta
oncostatin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310469.2NP_001297398.1  oncostatin-M-specific receptor subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297398.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is 1 amino acid shorter than isoform 1.
    Source sequence(s)
    AC102825, AC109183
    Consensus CDS
    CCDS79358.1
    UniProtKB/Swiss-Prot
    O70458, O88821
    UniProtKB/TrEMBL
    A0A0R4J268, B9EHD2
    Related
    ENSMUSP00000135204.2, ENSMUST00000176826.2
    Conserved Domains (4) summary
    smart00060
    Location:437512
    FN3; Fibronectin type 3 domain
    cd00063
    Location:621729
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:332413
    fn3; Fibronectin type III domain
    cl21522
    Location:230289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_011019.4NP_035149.2  oncostatin-M-specific receptor subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_035149.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AC102825, AC109183
    Consensus CDS
    CCDS27368.1
    UniProtKB/Swiss-Prot
    O70458, O88821
    UniProtKB/TrEMBL
    B9EHD2, G3X8V6
    Related
    ENSMUSP00000022746.7, ENSMUST00000022746.13
    Conserved Domains (4) summary
    smart00060
    Location:437512
    FN3; Fibronectin type 3 domain
    cd00063
    Location:622730
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:30137
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam00041
    Location:332413
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    6843049..6904434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159232.1XP_036015125.1  oncostatin-M-specific receptor subunit beta isoform X1

    UniProtKB/Swiss-Prot
    O70458, O88821
    UniProtKB/TrEMBL
    B9EHD2, G3X8V6
    Conserved Domains (4) summary
    smart00060
    Location:437512
    FN3; Fibronectin type 3 domain
    cd00063
    Location:622730
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:30137
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam00041
    Location:332413
    fn3; Fibronectin type III domain
  2. XM_006519973.5XP_006520036.1  oncostatin-M-specific receptor subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006520036.1

    UniProtKB/Swiss-Prot
    O70458, O88821
    UniProtKB/TrEMBL
    B9EHD2, G3X8V6
    Conserved Domains (4) summary
    smart00060
    Location:437512
    FN3; Fibronectin type 3 domain
    cd00063
    Location:622730
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:30137
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam00041
    Location:332413
    fn3; Fibronectin type III domain
  3. XM_030248385.2XP_030104245.1  oncostatin-M-specific receptor subunit beta isoform X2

    UniProtKB/TrEMBL
    B9EHD2
    Conserved Domains (3) summary
    smart00060
    Location:270345
    FN3; Fibronectin type 3 domain
    cd00063
    Location:455563
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:63122
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_004938808.1 RNA Sequence