U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Orc2 origin recognition complex, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 18393, updated on 1-Mar-2024

Summary

Official Symbol
Orc2provided by MGI
Official Full Name
origin recognition complex, subunit 2provided by MGI
Primary source
MGI:MGI:1328306
See related
Ensembl:ENSMUSG00000026037 AllianceGenome:MGI:1328306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc2l
Summary
Enables DNA replication origin binding activity. Predicted to be involved in DNA replication. Located in heterochromatin. Part of inner kinetochore and nuclear origin of replication recognition complex. Is expressed in several structures, including 1st branchial arch maxillary component; genitourinary system; liver; sensory organ; and spleen. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 14.2), liver E14.5 (RPKM 11.5) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Orc2 in Genome Data Viewer
Location:
1 C1.3; 1 29.1 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58501933..58544114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58462771..58505113, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58480276-58480459 Neighboring gene STARR-positive B cell enhancer ABC_E5756 Neighboring gene CDC-like kinase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58501960-58502147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58502340-58502523 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene STARR-seq mESC enhancer starr_01014 Neighboring gene STARR-positive B cell enhancer ABC_E3277 Neighboring gene predicted gene 15834 Neighboring gene STARR-seq mESC enhancer starr_01015 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E10012 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
part_of inner kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
origin recognition complex subunit 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025378.3NP_001020549.1  origin recognition complex subunit 2 isoform B

    See identical proteins and their annotated locations for NP_001020549.1

    Status: VALIDATED

    Source sequence(s)
    AC118698
    Consensus CDS
    CCDS14974.1
    UniProtKB/TrEMBL
    Q59IX1
    Related
    ENSMUSP00000109964.2, ENSMUST00000114325.8
    Conserved Domains (1) summary
    pfam04084
    Location:208513
    ORC2; Origin recognition complex subunit 2
  2. NM_001271526.2NP_001258455.1  origin recognition complex subunit 2 isoform A

    See identical proteins and their annotated locations for NP_001258455.1

    Status: VALIDATED

    Source sequence(s)
    AC118698
    Consensus CDS
    CCDS14975.1
    UniProtKB/Swiss-Prot
    Q60862
    UniProtKB/TrEMBL
    Q543F8
    Conserved Domains (1) summary
    pfam04084
    Location:255561
    ORC2; Origin recognition complex subunit 2
  3. NM_001420407.1NP_001407336.1  origin recognition complex subunit 2 isoform A

    Status: VALIDATED

    Source sequence(s)
    AC118698
    UniProtKB/Swiss-Prot
    Q60862
    UniProtKB/TrEMBL
    Q543F8
  4. NM_001420408.1NP_001407337.1  origin recognition complex subunit 2 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC118698
  5. NM_001420409.1NP_001407338.1  origin recognition complex subunit 2 isoform D

    Status: VALIDATED

    Source sequence(s)
    AC118698
  6. NM_001420410.1NP_001407339.1  origin recognition complex subunit 2 isoform B

    Status: VALIDATED

    Source sequence(s)
    AC118698
    UniProtKB/TrEMBL
    Q59IX1
  7. NM_001420411.1NP_001407340.1  origin recognition complex subunit 2 isoform E

    Status: VALIDATED

    Source sequence(s)
    AC118698
  8. NM_008765.4NP_032791.1  origin recognition complex subunit 2 isoform A

    See identical proteins and their annotated locations for NP_032791.1

    Status: VALIDATED

    Source sequence(s)
    AC118698
    Consensus CDS
    CCDS14975.1
    UniProtKB/Swiss-Prot
    Q60862
    UniProtKB/TrEMBL
    Q543F8
    Related
    ENSMUSP00000027198.6, ENSMUST00000027198.12
    Conserved Domains (1) summary
    pfam04084
    Location:255561
    ORC2; Origin recognition complex subunit 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58501933..58544114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)