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Orc2 origin recognition complex, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 18393, updated on 26-Sep-2022

Summary

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Official Symbol
Orc2provided by MGI
Official Full Name
origin recognition complex, subunit 2provided by MGI
Primary source
MGI:MGI:1328306
See related
Ensembl:ENSMUSG00000026037 AllianceGenome:MGI:1328306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc2l
Summary
Enables DNA replication origin binding activity. Predicted to be involved in DNA replication. Located in heterochromatin. Part of inner kinetochore and nuclear origin of replication recognition complex. Is expressed in several structures, including 1st branchial arch maxillary component; genitourinary system; liver; sensory organ; and spleen. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 14.2), liver E14.5 (RPKM 11.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Orc2 in Genome Data Viewer
Location:
1; 1 C1.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58501930..58544268, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58462771..58505113, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CDC-like kinase 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene predicted gene 15834 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Ortega MA, et al. Biol Reprod, 2012 Sep. PMID 22674395, Free PMC Article
  2. Diverse factors are involved in maintaining X chromosome inactivation. Chan KM, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21940502, Free PMC Article
  3. Mouse pre-replicative complex proteins colocalise and interact with the centrosome. Stuermer A, et al. Eur J Cell Biol, 2007 Jan. PMID 17157410
  4. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Takahara K, et al. Genomics, 1996 Jan 1. PMID 8808289
  5. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake Y, et al. J Biol Chem, 2005 Apr 1. PMID 15634681

See all (38) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
    Title: Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
  2. Depletion of Orc2 and Mcm3 by siRNA leads to an inhibition of cell proliferation, an altered cell cycle distribution as well as to multinucleated cells with insufficiently organised microtubules.
    Title: Mouse pre-replicative complex proteins colocalise and interact with the centrosome.
  3. mouse Orc1, Orc2, and Orc3 each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation
    Title: Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of inner kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025378.2 → NP_001020549.1  origin recognition complex subunit 2 isoform B

    See identical proteins and their annotated locations for NP_001020549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) has a shorter 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant a. It encodes isoform B which is shorter than isoform A.
    Source sequence(s)
    AB190256, AC118698, AK048408, BU923423
    Consensus CDS
    CCDS14974.1
    UniProtKB/TrEMBL
    Q543F8, Q59IX1
    Related
    ENSMUSP00000109964.2, ENSMUST00000114325.8
    Conserved Domains (1) summary
    pfam04084
    Location:208 → 513
    ORC2; Origin recognition complex subunit 2

  2. NM_001271526.1 → NP_001258455.1  origin recognition complex subunit 2 isoform A

    See identical proteins and their annotated locations for NP_001258455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) uses an alternate splice site in the 5' UTR compared to variant a. Both variants a and c encode the same isoform (A).
    Source sequence(s)
    AC118698, AK048408, AK146859, BU923423
    Consensus CDS
    CCDS14975.1
    UniProtKB/Swiss-Prot
    Q60862
    UniProtKB/TrEMBL
    Q543F8
    Conserved Domains (1) summary
    pfam04084
    Location:255 → 561
    ORC2; Origin recognition complex subunit 2

  3. NM_008765.3 → NP_032791.1  origin recognition complex subunit 2 isoform A

    See identical proteins and their annotated locations for NP_032791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (A). Both variants a and c encode the same isoform (A).
    Source sequence(s)
    AC118698, AK048408, BU923423
    Consensus CDS
    CCDS14975.1
    UniProtKB/Swiss-Prot
    Q60862
    UniProtKB/TrEMBL
    Q543F8
    Related
    ENSMUSP00000027198.6, ENSMUST00000027198.12
    Conserved Domains (1) summary
    pfam04084
    Location:255 → 561
    ORC2; Origin recognition complex subunit 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58501930..58544268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252150.2 → XP_030108010.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    Q59IX1
    Conserved Domains (1) summary
    pfam04084
    Location:208 → 513
    ORC2; Origin recognition complex subunit 2

  2. XM_011238453.4 → XP_011236755.1  origin recognition complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011236755.1

    UniProtKB/TrEMBL
    Q59IX1
    Conserved Domains (1) summary
    pfam04084
    Location:208 → 513
    ORC2; Origin recognition complex subunit 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60862.1 GenPept UniProtKB/Swiss-Prot:Q60862

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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